BX10: Immunology (6 ECTS)

STADS: 3235001

Level


Teaching period

Autumn semester

Teacher responsible
Email: kskjoedt@health.sdu.dk

Additional teachers
ckoch@health.sdu.dk
charken@health.sdu.dk

Timetable
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Comment:
Maksimalt deltagerantal 48 som deles på 3 hold

Prerequisites:
None

Academic preconditions:
Protein and Enzyme Chemistry (BX05), Molecular Biologi A (BM05) and Celle Biology and Histology (BC01).

Course introduction
To provide an understanding of immunological processes at the cellular and molecular level, and of the roles these processes play in protecting the host against infections. To give the student a working knowledge of various immunological techniques and of analytical approaches to characterising the immune system.

Expected learning outcome


Subject overview

Lectures:
The histological and cellular constitution of lymphoid tissues and their various roles in the development of immunological competence and the immune response.
The kinetics of an immune response.
The chemistry of immunoglobulins and the relationship between antibody structure and function.
The chemistry and classification of antigens.
The nature of antibody?antigen interactions and their modes of manifestation.
The nature of T cell interaction with antigen incl. the roles of MHC glycoproteins and antigen processing by antigen?presenting cells.
Immunogenetics.
Cellular interactions and cytokines involved in the induction and regulation of an immune response.
Effector mechanisms of the immune system.
The chemistry, reaction kinetics and immunological roles of the complement system.
The concepts humoral and cellular immunity.
Immunological tolerance.

Practicals:
Production of monoclonal antibodies.
Identification of antibody producing clones by ELISA.
Immunospecific affinity chromatography. Analysis of immunological cross reactions.
Definitions of antibody specificities by immunoelectrophoretic procedures.
Quantitative techniques based on antibodies (RIA, ELISA).
Western blots and immunoprecipitation.
Immunohistochemistry.
Immunofluorescence and flowcytometry.


Literature

• Kindt, Osborne, Goldsby: Kuby Immunology, 6th Edition, 2006, W. H. Freeman (publisher).
• Agger, Andersen, Leslie, Aasted: Immunologi, 4. udgave, 2005, Biofolia (forlag).
• Parham, P.: The Immune System (foretrækkes af underviser), 2nd Edition, 2004, Garland (publisher).
• Goldsby, Kindt, Osborne, Kuby: Immunlogi (er stadig pensumdækkende), 5th Edition, W. H. Freeman (publisher).
• Øvelsesvejledning.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
4 hour written examination without reference books. Marks according to the Danish 13?point marking scale. External examiner.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger 18 timer og laboratorieøvelser 42 timer.
Educational activities

Language
No recorded information about the language used in the course.

Remarks
The course is run by the Department of Medical Microbiology

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.