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BB524: Pharmaceutical toxicology B (5 ECTS)

STADS: 04014101

Level
Bachelor course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: klp@biology.sdu.dk

Additional teachers
hol@biology.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 08-12 U20 20
Common I Tuesday 08-10 U20 7,10,14
Common I Tuesday 08-10 U150 11
Common I Tuesday 10-12 U47 21
Common I Wednesday 12-14 U55 17 Del-eksamen
Common I Wednesday 10-12 U48A 21 Del-eksamen
Common I Thursday 08-10 U20 7
Common I Friday 12-14 U55 13
H1 TE Tuesday 08-10 U20 6
H1 TL Tuesday 14-18 Yellow Lab 13-14,16-17
H1 TE Thursday 10-12 U20 7-8
H2 TE Tuesday 08-10 U20 6
H2 TE Thursday 10-12 U20 7-8
H2 TL Thursday 14-18 Yellow Lab 13
H2 TL Friday 09-13 Yellow Lab 14,16-17
H3 TE Tuesday 08-10 U20 6
H3 TE Thursday 10-12 U20 7-8
H3 TL Friday 14-18 Yellow Lab 13-14,16-17
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 Show personal time table for this course.

Prerequisites:
None

Academic preconditions:
Students taking the course are expected to:
  • Have knowledge of basic chemistry, molecular biological concepts and biochemical processes
  • Have a knowledge of basic toxicological concepts
  • Be able to use basic laboratory equipment and perform simple concentration and dilution calculations.
  • Basic knowledge of toxicology at the level of BB523: Pharmaceutical Toxicology or BB526: Elementary ecotoxicology expected.


Course introduction
The aim of the course is to enable the student to understand the toxicological data on substances through a thorough knowledge of the mechanisms of toxicity and the body's defense mechanisms against toxic effects. This is important in terms of understanding the mechanisms of side effects and toxic reactions to pharmaceuticals, as well as for the understanding of food-drug, drug-drug and drug-pollutant interactions. This knowledge is necessary for pharmacists to advise in pharmacies as well as for pharmacists and biologists aiming to work in the pharmaceutical industry and environmental regulation.
The course builds on the knowledge acquired in the course Pharmaceutical Toxicology A (BB523) for pharmacists and biologists and provide a scientific basis for studying the topics Mechanistic Toxicology (pharmacists) and Molecular Toxicology (biologists) that is located on the Master's program.
 


Expected learning outcome
The learning objective of the course is that the student demonstrates the ability to:
  • Explain how nuclear receptors are part of key metabolic and transport processes as well as their role in toxicity
  • Describe the impact on hormone systems of pollutants and pharmaceutika
  • Explain the molecular mechanisms behind toxicity of selected groups of substances.
  • Explain the mechanisms behind the combination effects of substances
  • Explain the factors that impede the use of results from animal studies for predicting toxicity in humans
  • Explain the sources of pharmaceuticals in nature and effects on wildlife.
  • Perform and report quantitative biochemical laboratory tests
 
 


Subject overview
The following main topics are contained in the course:
  • Nuclear Receptor-mediated toxicity
  • Effects of endocrine disrupters on human reproduction
  • Molecular mechanisms underlying the toxicity of metals and natural toxins from plants and fungi
  • Sources of species differences in toxicity
  • Effects of pharmaceutika on the environment
 


Literature
    Oplyses senere


Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:


Expected working hours
The teaching method is based on three phase model.
Intro phase: 20 hours
Skills training phase: 33 hours, hereof:
 - Tutorials: 17 hours
 - Laboratory exercises: 16 hours

Educational activities
NoneEducational form
The teaching will consist of short introductory lectures on the subjects, which then will be worked out in detail in the form of dialogue through questions. There is thus no special lectures or tutorials. All hours are a mix of lectures, assignments in small groups and shared dialogue on the responses. The laboratory work is closely linked to the theory from the course about nuclear receptor-mediated toxicity. The laboratory part ends with a plenum review of reports in order to ensure that the theoretical, academic level has been reached and that work is reported in a professional manner.

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.