BM119: Mechanisms of Eukaryotic Cell Signalling (10 ECTS)

STADS: 0103161

Level


Teaching period

Spring semester.

Teacher responsible
Email: bab@bmb.sdu.dk

Additional teachers
ihk@bmb.sdu.dk
jens.andersen@bmb.sdu.dk

Timetable
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Prerequisites:
None

Academic preconditions:
For SDU students: BM113 or BMB503 Fundamental Biochemistry & BMB505 Metabolic regulation must be passed

Course introduction
To give students a thorough introduction to signalling events which underlie eukaryote cell function and dysfunction. Mechanism by which extracellular signals are transmitted to cells and exert their effects will be discussed. Participants will learn about the roles of signalling molecules such as hormones, receptors, kinases, and transcription factors. Participants will also gain experience in reading original research articles and in oral and written presentation of scientifc results.

Expected learning outcome


Subject overview
Principles of signalling networks
Growth factor signalling
Growth factor signalling in cancer
PI3K-signalling
G-coupled-receptor signalling
Transforming growth factor beta (TGF-beta) signalling and its involvement in cancer
Integrin signalling
Tumor necrosis factor (TNF) and NF-kappa B-signalling
Calcium signalling

Literature

• Harvey Lodish: Molecular Cell Biology, W.H. Freeman.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Students will give short presentations of original research articles. They must attend at least 80% of the scheduled hours and participate actively in discussions following the presentations.
They will also prepare a short synopsis about a signalling topic. Instructors will advice in the preparation of this synopsis, which will also be the basis for the course grade according to the Danish 7-point scale with an external examiner.

Expected working hours
The teaching method is based on three phase model.

Lectures (24 hours), student presentations (12 hours) tutorials (20 hours)
Educational activities

Language
This course is taught in English.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
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