BMB504: Fundamental Molecular Biology (5 ECTS)

STADS: 01000401

Level
Bachelor course

Teaching period
The course is offered in the autumn semester.
Second quarter.

Teacher responsible

Email: srd@bmb.sdu.dk

Additional teachers

f.kir@bmb.sdu.dk

Timetable

Group	Type	Day	Time	Classroom	Weeks
Common	I	Monday	10-12	U55	50
Common	I	Wednesday	10-12	U55	44,46,48
Common	I	Wednesday	10-12	U55	50
Common	I	Thursday	08-10	U55	45-47
Common	I	Friday	14-16	U55	44
Common	I	Friday	14-16	U110	47
S1	TE	Tuesday	12-14	U130	49
S1	TE	Wednesday	08-10	U142	45-51
S2	TE	Thursday	10-12	U145	44-51
S3	TE	Wednesday	16-18	U142	49-51
S3	TE	Friday	12-14	U145	44-48
S4	TE	Monday	14-16	U151	49
S4	TE	Tuesday	14-16	U145	50-51
S4	TE	Friday	10-12	U145	45-48
S4	TE	Friday	14-16	U143	49
S5	TE	Monday	08-10	U133	44-51
S6	TE	Monday	14-16	U26a	45-48
S6	TE	Tuesday	16-18	U147	49
S6	TE	Friday	08-10	U91	49-51
S7	TE	Thursday	14-16	U145	44-51

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Prerequisites:
None

Academic preconditions:
BMB501 must be passed.

Course introduction
The course aims to give a general introduction to molecular biological systems in both prokaryotes and eukaryotes. Students will learn about the structure of large biological macromolecules (DNA, RNA and proteins) as well as their functions in the storage and transfer of genetic information in living cells. The course gives the basic knowledge that is necessary for the more advanced courses in molecular biology.

Qualifications
Students will gain a broad insight into the field of molecular biology, and will learn how to use this knowledge, for example:
- to understand scientific questions and terms within molecular biology’s central disciplines
- to understand how genetic information is conveyed in all living cells, according to the central dogma of molecular biology
- to be able to express oneself using precise scientific and technical terminology
- to take an educated position regarding controversial scientific questions, including for example genetically modified organisms
- to be able to understand and evaluate information concerning molecular biology that is presented in the media and scientific literature

Expected learning outcome

Subject overview
The following subjects will be presented and discussed: 1. Information flow through macromolecules from gene to protein
2. Genome organisation in pro- og eukaryotes
3. Structure and function of nucleic acids (DNA and RNA) that are involved in the flow of information
4. Replication of DNA, including regulation of DNA synthesis
5. Mechanisms of DNA recombination
6. Mutation of DNA and its repair
7. Mechanisms of transposition
8. Synthesis of RNA by transcription from DNA
9. Regulation of gene expression
10. Processing of RNA including splicing of mRNA
11. Ribosome’s structure and how it function in protein synthesis
12. Protein localization and export
13. Proteins involved in the control of cell division
14. Antibiotics and cytotoxins
15. Fundamental techniques within molecular biology including PCR, arrays and gel shift assays

Literature

Stryer: Biochemestry, 7. edt.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
A three-hour written exam with books, notes, etc; marked by an external examiner according to the Danish 7-scale.

Re-examination after 4th quarter.

Expected working hours
The teaching method is based on three phase model.

Undervisningen vil bestå af forelæsninger (24 timer), som suppleres med eksaminatorier (16 timer).
Educational activities

Language
No recorded information about the language used in the course.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.