BMB504: Fundamental Molecular Biology (5 ECTS)

STADS: 01012401

Level
Bachelor course

Teaching period
The course is offered in the autumn semester.

Teacher responsible

Email: sjf@bmb.sdu.dk

Email: kwr@bmb.sdu.dk

Additional teachers

jonasb@bmb.sdu.dk

Timetable

Group	Type	Day	Time	Classroom	Weeks
Common	I	Wednesday	08-09	U140	36-37
Common	I	Wednesday	09-10	U140	38-41,43-51
Common	I	Friday	14-15	U140	37-38,40-41,45-48,50-51
Common	I	Friday	13-14	U50A	39,49
Common	I	Friday	13-14	U55	43
H1	TE	Monday	10-12	U23A	39
H1	TE	Monday	12-14	U17	40-41,43-44,47,49-50
H1	TE	Monday	12-14	U143	48
H1	TE	Tuesday	10-12	U17	51
H2	TE	Monday	08-10	U17	51
H2	TE	Tuesday	08-10	U23A	39-41,43-44,47-50
H3	TE	Tuesday	14-16	U17	51
H3	TE	Thursday	08-10	U141	39-41,43-44,47,49-50
H3	TE	Thursday	08-10	U23A	48
H4	TE	Monday	12-14	U145	51
H4	TE	Thursday	12-14	U23A	39-41,43-44,47-50
H5	TE	Monday	15-17	U17	51
H5	TE	Tuesday	12-14	U141	39-41,43-44,47,49-50
H5	TE	Tuesday	12-14	U23A	48
H6	TE	Tuesday	16-18	U17	51
H6	TE	Wednesday	16-18	U23A	48
H6	TE	Thursday	14-16	U17	44
H6	TE	Friday	08-10	U17	39-41,43,47,49-50

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Prerequisites:
None

Academic preconditions:
FF503 is assumed to be known.

Course introduction
The course aims to give a general introduction to molecular biological systems in both prokaryotes and eukaryotes. Students will learn about the structure of large biological macromolecules (DNA, RNA and proteins) as well as their functions in the storage and transfer of genetic information in living cells. Furthermore, the course introduces relations between the structure and function of proteins and how selected macromolecules interact with other biomolecules or drugs.

Qualifications
Students will gain a broad insight into the field of molecular biology, and will learn how to use this knowledge, for example:

to understand scientific questions and terms within molecular biology’s central disciplines
to understand how genetic information is conveyed in all living cells, according to the central dogma of molecular biology
to be able to express oneself using precise scientific and technical terminology
to be able to understand and evaluate information concerning molecular biology that is presented in the media and scientific literature

Expected learning outcome

Subject overview
The following subjects will be presented and discussed:

Information flow through macromolecules from gene to protein
Structure and function of nucleic acids (DNA and RNA) that are involved in the flow of information
Replication of DNA, including regulation of DNA synthesis
Mutation of DNA and its repair
Synthesis of RNA by transcription from DNA
Regulation of gene expression
Processing of RNA including splicing of mRNA
Ribosome’s structure and how it function in protein synthesis
Fundamental techniques within molecular biology
Protein structure, -folding, and -function relationships
Protein misfolding and related diseases
Posttranslational modifications of proteins and their role in signal transduction
Protein degradation
Structure and fuction of antibodies in the immunesystem and as medicine

Literature

Jeremy M Berg, John L Tymoczko & Lubert Stryer: Biochemistry, 8. Udgave.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
Six electronic test during the course, of which at least three must be handed in within the time stated. Tests are carried out in Blackboard. Dates and intervals will also be published via Blackboard

Assessment and marking:
A three-hour written exam with aids; marked by an external examiner according to the Danish 7-mark scale.

Re-examination in the same exam period or immediately thereafter.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 30 hours
Skills training phase: 18 hours, hereof:
- Tutorials: 18 hours

Educational activities Study phase: 34 hours

Language
This course is taught in English.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.