BMB505: Metabolic regulation (10 ECTS)

STADS: 01007101

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd and 4th quarter.

Teacher responsible
Email: nils.f@bmb.sdu.dk

Additional teachers
wuestner@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Revison of timetable:
: Skemaændringer hold S2 efter ønske
: Skemaændringer hold S2 efter ønske

Comment:
Laboratorieøvelsen afholdes under 3. kvartal.

Prerequisites:
None

Academic preconditions:
BMB502 Enzymes and membranes must be attended. Knowledge of BMB503 Fundamental biochemistry is a prerequisite .

Course introduction
The course aims to give an understanding of metabolic pathways in mammalian cells and their regulation at a molecular level. Participants will gain insights into signal transduction pathways incl. hormones, growth factors, receptors, kinases, calcium and transcription factors.

Expected learning outcome


Subject overview

1. Regulation of glycolysis/gluconeogenesis/TCA
2. Lipidabsorption, transport and lipoproteins
3. Fatty acid degradation
4. Fatty acid synthesis
5. Compleks lipidsynthesis
6. Amino acid metabolism
7. Signal transduction
8. Regulation of metabolism incl. glucose-fatty acid cycle
9. Integration of metabolism
10. Ca++-signalling
11. Metabolic diseases

The glucose-fatty acid cycle as well as integration of metabolism will be illustrated via a practical exercise/obligatory assignment.

Literature

• Lehninger: Principles of Biochemistry, 5. udgave .
• David L. Nelson and Michael M. Cox: Metabolic Regulation, a human perspective , . , 2. udgave K. Frayn .
• Øvelsesvejledning.

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Number of evaluations: 3.

a) Practicals/Obligatory assignment (3rd quarter). Internal censorship by teachers. Pass/fail (2 ECTS). The report is made by three students together. The report must be passed in order to take the final electronic exam.
b) Oral presentation and report (max 5 pages) that cover metabolic disease. Internal evaluation by teacher, pass/fail (2 ECTS). The presentation and report are made by 4-5 students together. The activity must be passed to take the final electronic exam.
c) Written take-home exam. Eksternal censorship, 7-point grading scale. The exam will be released via Black Board and the stuedent will get 4 hours to answer the questions and submit the answers via Black Board as a word or pdf file.

Re-examination after 2nd quarter. br> The mode of exam at the reexamination may differ from the mode of exam at the ordinary exam.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger (44 timer hvoraf 16 afholdes som kollokvier), eksaminatorier (26 timer) og laboratorieøvelser (10 timer).
Educational activities

Language
This course is taught in Danish.

Remarks
It is expected that student participates actively in at least 80% of the collquiums.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.