English

BMB505: Metabolic regulation (10 ECTS)

STADS: 01010301

Level
Bachelor course

Teaching period
The course is offered in the spring semester.

Teacher responsible

Email: nils.f@bmb.sdu.dk

Additional teachers

wuestner@bmb.sdu.dk

Timetable

Group	Type	Day	Time	Classroom	Weeks
Common	I	Monday	12-14	U55	16
Common	I	Monday	16-18	Kollokvier i U140	18-19,21
Common	I	Monday	10-12	Kollokvier i U140	20
Common	I	Tuesday	12-14	U45	06-08,10-11,13,15,17-21
Common	I	Wednesday	12-14	Kollokvier i U140	17
Common	I	Wednesday	16-18	Kollokvier i U140	18,20
Common	I	Thursday	10-12	Kollokvier i U140	17
Common	I	Thursday	08-10	Kollokvier i U140	19,21
Common	I	Friday	10-12	U55	06
Common	I	Friday	08-10	U45	12
S1	TE	Tuesday	15-17	U142	18,20
S1	TE	Wednesday	10-12	U156	15
S1	TL	Thursday	08-13	BMB øvelseslab	08,10
S1	TE	Thursday	10-12	U145	12
S1	TE	Friday	08-10	U30a	07-08,10-11,13
S1	TE	Friday	08-10	U49b	17,19
S1	TE	Friday	08-10	U155	21-22
S2	TE	Monday	14-16	U145	07-08,10-13,18-22
S2	TE	Tuesday	15-17	U142	17
S2	TE	Wednesday	14-16	U154	15
S2	TL	Thursday	13-18	BMB øvelseslab	08,10
S3	TE	Tuesday	12-14	Diamant BMB	22
S3	TE	Wednesday	08-10	U155	07-08,10-13,17-21
S3	TE	Thursday	10-12	U156	15
S3	TL	Friday	10-15	BMB øvelseslab	08,10

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Comment:
Laboratorieøvelsen afholdes under 3. kvartal. Samlæses med BMB521

Prerequisites:
None

Academic preconditions:
BMB502 Enzymes and membranes og BMB532 must be attended. Knowledge of BMB503 or BMB532 Fundamental biochemistry is a prerequisite .

Course introduction
The course aims to give an understanding of metabolic pathways in mammalian cells and their regulation at a molecular level. Participants will gain insights into signal transduction pathways incl. hormones, growth factors, receptors, kinases, calcium and transcription factors.

Expected learning outcome

Subject overview

Regulation of glycolysis/gluconeogenesis/TCA
Lipidabsorption, transport and lipoproteins
Fatty acid degradation
Fatty acid synthesis
Compleks lipidsynthesis
Amino acid metabolism
Signal transduction
Regulation of metabolism incl. glucose-fatty acid cycle
Integration of metabolism
Ca++-signalling
Metabolic diseases

The glucose-fatty acid cycle as well as integration of metabolism will be illustrated via a practical exercise/obligatory assignment.

Literature

David L. Nelson and Michael M. Cox: Lehninger Principles of Biochemistry, 6. Udgave.
K. Frayn: Metabolic Regulation, a human perspective, 3. Udgave.
Øvelsesvejledning.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Number of evaluations: 3.

a) Practicals/Obligatory assignment (3rd quarter). Internal censorship by teachers. Pass/fail (2 ECTS). The report is made by three students together. The report must be passed in order to take the final electronic exam.
b) Oral presentation and report (max 5 pages) that cover metabolic disease. Internal evaluation by teacher, pass/fail (2 ECTS). The presentation and report are made by 4-5 students together. The activity must be passed to take the final electronic exam.
c) Written take-home exam. Eksternal censorship, 7-point grading scale. The exam will be released via Black Board and the stuedent will get 4 hours to answer the questions and submit the answers via Black Board as a word or pdf file.

Re-examination after 2nd quarter. br> The mode of exam at the reexamination may differ from the mode of exam at the ordinary exam.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger (44 timer hvoraf 16 afholdes som kollokvier), eksaminatorier (26 timer) og laboratorieøvelser (10 timer).
Educational activities

Language
This course is taught in Danish.

Remarks
It is expected that student participates actively in at least 80% of the collquiums.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.