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BMB505: Metabolic regulation (10 ECTS)

STADS: 01011201

Level
Bachelor course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: nils.f@bmb.sdu.dk

Additional teachers
wuestner@bmb.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 10-12 U55 10
Common I Monday 10-12 U140 18
Common I Tuesday 14-16 U55 06
Common I Tuesday 10-12 U55 12
Common I Tuesday 10-11 U55 20-22
Common I Wednesday 14-15 U140 18
Common I Thursday 10-12 U55 06,08,10,12-13,15-18,21
Common I Friday 08-10 U55 20
H1 TE Monday 14-16 U147 07-08
H1 TE Monday 14-16 U131 10-11,13
H1 TE Monday 10-12 U157 12
H1 TE Monday 14-16 U52 16-21
H1 TE Tuesday 14-16 U51 22
H1 TL Thursday 14-19 U155 13
H1 TL Friday 14-19 Red Lab 15
H1 TE Friday 10-12 U51 15
H2 TL Tuesday 12-17 Red Lab 15
H2 TE Wednesday 08-10 U155 07-08,10-13,16-19,21-22
H2 TE Wednesday 08-10 U157 15
H2 TL Friday 14-19 U154 13
H2 TE Friday 10-12 U157 20
H3 TE Tuesday 08-10 U147 07
H3 TE Tuesday 08-10 U154 08
H3 TE Tuesday 08-10 U30 11,13,15-22
H3 TE Wednesday 10-12 U30 10
H3 TL Wednesday 12-17 U51 13
H3 TL Wednesday 12-17 Red Lab 15
H3 TE Thursday 08-10 U131 12
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Prerequisites:
None

Academic preconditions:
Knowledge of BMB503 or BMB532 Fundamental biochemistry is expected.

Course introduction
The course aims to give an understanding of metabolic pathways in mammalian cells and their regulation at a molecular level. Participants will gain insights into signal transduction pathways incl. hormones, growth factors, receptors, kinases, calcium and transcription factors.

Expected learning outcome


Subject overview
  1. Regulation of glycolysis/gluconeogenesis/TCA
  2. Lipidabsorption, transport and lipoproteins
  3. Membrane trafficking
  4. Fatty acid degradation
  5. Fatty acid synthesis
  6. Compleks lipidsynthesis
  7. Amino acid metabolism
  8. Signal transduction
  9. Regulation of metabolism incl. glucose-fatty acid cycle
  10. Integration of metabolism
  11. Ca++-signalling
  12. Metabolic diseases

The glucose-fatty acid cycle as well as integration of metabolism will be illustrated via a practical exercise/obligatory assignment.



Literature
  • David L. Nelson and Michael M. Cox: Lehninger Principles of Biochemistry, 6. Udgave.
  • K. Frayn: Metabolic Regulation, a human perspective, 3. Udgave.
  • Øvelsesvejledning.


Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
The course is evaluated by a portfolio examination, which consists of two different activities:

  1. An individual exercise report, which accounts for 25 % of the final grade. Internal censorship.
  2. 4-hours electronic exam without any books/notes etc. This activity accounts for 75 % of the final grade. Internal censorship.

The final grade will be announced when all activities have been completed. Grade after the Danish 7-mark scale.

Re-examination no later than 6 weeks after the ordinary examination. The mode of exam at the reexamination may differ from the mode of exam at the ordinary exam.

Date of exam
The ordinary exam takes place on June 8, 2015
The re-examination takes place on August 7, 2015

Expected working hours
The teaching method is based on three phase model.

36 lectures. 26 instructor classes, and 10 hours practicals/assignments.
Educational activities

Language
This course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.