BMB508: Advanced Molecular Biology (10 ECTS)

STADS: 01002901

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd and 4th quarter.

Teacher responsible

Email: kak@bmb.sdu.dk

Timetable

Group	Type	Day	Time	Classroom	Weeks
Common	I	Monday	15-16	U9	06-07
Common	I	Monday	15-16	U27	09-10
Common	I	Monday	08-10	U44	15-18
Common	I	Tuesday	14-16	U44	06, 09-10
Common	I	Tuesday	15-17	U44	07
Common	I	Tuesday	14-15	U44	15-18
Common	I	Wednesday	08-10	U44	06-07, 09-10
Common	I	Wednesday	08-10	U27	15-18
S1	TL	Monday	08-13	BMB	21-22
S1	TL	Tuesday	13-18	BMB	21
S1	TE	Thursday	12-13	U9	06-07, 09, 11
S1	TE	Thursday	12-13	U64	15-17,19
S1	TE	Friday	10-12	U44	06
S1	TE	Friday	08-10	U133	07
S1	TE	Friday	10-12	U44	09,15,17-19
S1	TE	Friday	10-12	U10	10
S2	TL	Monday	13-18	BMB	21
S2	TL	Tuesday	08-13	BMB	21-22
S2	TE	Thursday	13-14	U14	06
S2	TE	Thursday	13-14	U9	07,09,11
S2	TE	Thursday	13-14	U70	15-17,19
S2	TE	Friday	13-15	U14	06
S2	TE	Friday	13-15	U69	07,09-10,15,18
S2	TE	Friday	13-15	U37	17
S2	TE	Friday	12-14	U69	19

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Revison of timetable:
: Al undervisning i lokale U14 flyttet til andre lokaler.
: Fredag uge 7 hold S1 flyttet fra kl. 10-12 til kl. 08-10.

Prerequisites:
None

Academic preconditions:
Passed BB501 Biology from molecule to ecosystem. Knowledge of the content of BMB504 Fundamental Molecular Biology.

Students who has passed BM114 cannot participate in this course.

Course introduction
The course represents a continuation of the course ”Fundamental Molekylær Biologi, and the aim is to provide a coherent understanding of the transmission and exchange of genetic information, to provide knowledge of the characteristics of biological processes at the molecular level in prokaryotes and eukaryotes, and how these processes differ between prokaryotes and eukaryotes. Examples comprising a diverse range organisms including man will be used to illustrate cellular functions and developmental processes.

Expected learning outcome

Subject overview
The course will cover the following topics:

1. Eukaryotic genome organization and replication
2. Methods for analysis of gene function, recombinant DNA technology, gene arrays, transgenic and knockout animals, ethical considerations
3. Regulation of transcription in eukaryotes
4. Posttranscriptional regulation, RNA modification, processing, splicing, catalytic RNA and nuclear-cytoplasmic transport
5. Translation of mRNA in eukaryote organisms. Protein localization and export
6. Control of gene activity via cellular signaling (signal transduction) and integration of celluæar signaling in the control of gene expression
7. Metabolic control at the molecular level
8. Control of the cell cycle in eukaryote organisms
9. Cancer at the molecular level, oncogenes, tumor suppressors, DNA damage and repair, signal transduction, hormones and receptors

Literature

Lodish et al.: Molecular Cell Biology, 6th edition (2007).

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Number of evaluations: 2.

Approval by teacher of report on laboratory exercises. Written examination (4 hours) with no books, and marks according to the Danish 7 point grading system with external examinators.

Expected working hours
The teaching method is based on three phase model.

Undervisningen vil bestå af forelæsninger (40 timer), som suppleres med eksaminatorier (24 timer) og laboratorieøvelser (15 timer). Kommunikation mellem lærerne og de studerende med hensyn til forelæsningsnoter, opgaver m.m. vil foregå via SDU’s e-learning system.
Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.