BMB508: Advanced Molecular Biology (10 ECTS)

STADS: 01002901

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd and 4th quarter.

Teacher responsible

Email: bragea@bmb.sdu.dk

Additional teachers

jens.andersen@bmb.sdu.dk

Timetable

Group	Type	Day	Time	Classroom	Weeks
Common	I	Monday	08-10	U20	05-07, 09-10, 16-18
Common	I	Wednesday	10-12	U47	05-07,09-10
Common	I	Wednesday	11-13	U55	16-17,19
Common	I	Thursday	12-13	U20	05-07, 10, 16-18
S1	TL	Monday	13-18	BMB´s øvelseslokale	20
S1	TE	Tuesday	10-12	U26	08
S1	TE	Tuesday	10-12	U48A	09-10,18-20
S1	TE	Wednesday	14-16	U27	08-10
S1	TE	Thursday	08-10	U133	18,20
S1	TL	Thursday	13-18	BMB´s øvelseslokale	20-21
S1	TE	Friday	12-14	U26	19
S2	TE	Monday	12-14	U27	18-19
S2	TL	Monday	08-13	BMB´s øvelseslokale	20
S2	TE	Tuesday	12-14	U26	08
S2	TE	Tuesday	12-14	U48A	09-10,18-20
S2	TL	Wednesday	08-13	BMB´s øvelseslokale	20-21
S2	TE	Friday	10-12	U9	08-10
S2	TE	Friday	12-14	U26	20
S3	TL	Tuesday	08-13	BMB´s øvelseslokale	20
S3	TL	Friday	12-17	BMB´s øvelseslokale	20-21

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Revison of timetable:
: Forelæsning onsdag uge 18 flyttet til uge 19 samme tid og sted efter ønske.

Comment:
Samlæses med BMB809

Prerequisites:
None

Academic preconditions:
Passed BB501 Biology from molecule to ecosystem. Knowledge of the content of BMB504 Fundamental Molecular Biology.

Students who has passed BM114 cannot participate in this course.

Course introduction
The course represents a continuation of the course ”Fundamental Molekylær Biologi, and the aim is to provide a coherent understanding of the transmission and exchange of genetic information, to provide knowledge of the characteristics of biological processes at the molecular level in prokaryotes and eukaryotes, and how these processes differ between prokaryotes and eukaryotes. Examples comprising a diverse range organisms including man will be used to illustrate cellular functions and developmental processes.

Expected learning outcome

Subject overview
The course will cover the following topics:

1. Eukaryotic genome organization and replication
2. Methods for analysis of gene function, recombinant DNA technology, gene arrays, transgenic and knockout animals, ethical considerations
3. Regulation of transcription in eukaryotes
4. Posttranscriptional regulation, RNA modification, processing, splicing, catalytic RNA and nuclear-cytoplasmic transport
5. Translation of mRNA in eukaryote organisms. Protein localization and export
6. Control of gene activity via cellular signaling (signal transduction) and integration of celluæar signaling in the control of gene expression
7. Metabolic control at the molecular level
8. Control of the cell cycle in eukaryote organisms
9. Cancer at the molecular level, oncogenes, tumor suppressors, DNA damage and repair, signal transduction, hormones and receptors

Literature

Lodish et al.: Molecular Cell Biology: Molecular Cell Biology, 6th edition (2007).

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Number of evaluations: 2.

Approval by teacher of report on laboratory exercises. Written examination (4 hours) with no books, and marks according to the Danish 7 point grading system with external examinators.

Expected working hours
The teaching method is based on three phase model.

Undervisningen vil bestå af forelæsninger (40 timer), som suppleres med eksaminatorier (24 timer) og laboratorieøvelser (15 timer). Kommunikation mellem lærerne og de studerende med hensyn til forelæsningsnoter, opgaver m.m. vil foregå via SDU’s e-learning system.
Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.