BMB508: Advanced Molecular Biology (10 ECTS)

STADS: 01002901

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd and 4th quarter.

Teacher responsible
Email: bragea@bmb.sdu.dk

Additional teachers
jens.andersen@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Revison of timetable:
: Hold S1 ekstra E-timer torsdag uge 8 kl. 08-10.
: Skemaændringer

Comment:
Samlæses med BMB809

Prerequisites:
None

Academic preconditions:
Passed BB501 Biology from molecule to ecosystem. Knowledge of the content of BMB504 Fundamental Molecular Biology.

Students who has passed BM114 cannot participate in this course.

Course introduction
The course represents a continuation of the course ”Fundamental Molekylær Biologi, and the aim is to provide a coherent understanding of the transmission and exchange of genetic information, to provide knowledge of the characteristics of biological processes at the molecular level in prokaryotes and eukaryotes, and how these processes differ between prokaryotes and eukaryotes. Examples comprising a diverse range organisms including man will be used to illustrate cellular functions and developmental processes.

Expected learning outcome


Subject overview
The course will cover the following topics:

1. Eukaryotic genome organization and replication
2. Methods for analysis of gene function, recombinant DNA technology, gene arrays, transgenic and knockout animals, ethical considerations
3. Regulation of transcription in eukaryotes
4. Posttranscriptional regulation, RNA modification, processing, splicing, catalytic RNA and nuclear-cytoplasmic transport
5. Translation of mRNA in eukaryote organisms. Protein localization and export
6. Control of gene activity via cellular signaling (signal transduction) and integration of celluæar signaling in the control of gene expression
7. Metabolic control at the molecular level
8. Control of the cell cycle in eukaryote organisms
9. Cancer at the molecular level, oncogenes, tumor suppressors, DNA damage and repair, signal transduction, hormones and receptors

Literature

• Lodish et al: Molecular Cell Biology: Molecular Cell Biolog, , 6th edition (2007).

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Number of evaluations: 2.

Approval by teacher of report on laboratory exercises. Written examination (4 hours) with no books, and marks according to the Danish 7 point grading system with external examinators.

Expected working hours
The teaching method is based on three phase model.

Undervisningen vil bestå af forelæsninger (40 timer), som suppleres med eksaminatorier (24 timer) og laboratorieøvelser (15 timer). Kommunikation mellem lærerne og de studerende med hensyn til forelæsningsnoter, opgaver m.m. vil foregå via SDU’s e-learning system.
Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.