BMB508: Advanced Molecular Biology (10 ECTS)

STADS: 01009401

Level
Bachelor course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: jens.andersen@bmb.sdu.dk

Additional teachers
bragea@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Revison of timetable:
: Laboratorietimerne for hold S1 i BMB508 om onsdagen fra kl. 13-18 i ugerne 20-21, har følgende ændringer: Hold ændret fra S1 til S3
: for hold 1 i BMB508 om tirsdagen fra kl. 16-18 i uge 18, har følgende ændringer: Lokale ændret fra TE til Hold ændret fra 1 til S1

Comment:
Samlæses med BMB809

Prerequisites:
None

Academic preconditions:
BB501 Biology from molecule to ecosystem or FF503 must be passed. It is required that the content of the course BMB504 Fundamental Molecular Biology is known.



Course introduction
The course represents a continuation of the course ”Fundamental Molekylær Biologi, and the aim is to provide a coherent understanding of the transmission and exchange of genetic information, to provide knowledge of the characteristics of biological processes at the molecular level in prokaryotes and preferentially eukaryotes, and how these processes differ between prokaryotes and eukaryotes. Examples comprising a diverse range organisms including man will be used to illustrate cellular functions and developmental processes.

Expected learning outcome


Subject overview
The course will cover the following topics:

1. Eukaryotic genome organization and replication
2. Methods for analysis of gene function, recombinant DNA technology, gene arrays, transgenic and knockout animals, ethical considerations
3. Regulation of transcription in eukaryotes
4. Posttranscriptional regulation, RNA modification, processing, splicing, catalytic RNA and nuclear-cytoplasmic transport
5. Translation of mRNA in eukaryote organisms. Protein localization and export
6. Control of gene activity via cellular signaling (signal transduction) and integration of celluæar signaling in the control of gene expression
7. Metabolic control at the molecular level
8. Control of the cell cycle in eukaryote organisms
9. Cancer at the molecular level, oncogenes, tumor suppressors, DNA damage and repair, signal transduction, hormones and receptors

Literature

• Lodish: Molecular Cell Biology, Seventh Edition 2013. (ISBN 978-1-4641-0981-2).

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:

1. Approval by teacher of report on laboratory exercises. Pass/fail. 
2. Approval of case study reports, pass/fail with internal evaluation be teacher.
3. Written examination (4 hours) with no books, and marks according to the Danish 7 point grading system with external examinators.

Reexamination in the same exam period or immediately thereafter

Expected working hours
The teaching method is based on three phase model.
Intro phase: 40 hours
Skills training phase: 39 hours, hereof:
 - Tutorials: 24 hours
 - Laboratory exercises: 15 hours

Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.