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Dansk English

BMB508: Advanced Molecular Biology (10 ECTS)

STADS: 01013601

Level
Bachelor course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: jens.andersen@bmb.sdu.dk

Additional teachers
s.mandrup@bmb.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 09-10 U140 5
Common I Monday 14-16 U55 10,15,17-19
Common I Tuesday 12-14 U140 9
Common I Wednesday 14-16 U55 13-14,20
Common I Thursday 14-16 U55 9,11,16
Common I Thursday 12-14 U48A 10
Common I Thursday 12-14 U55 19
Common I Friday 14-16 U55 11
H1 TL Monday 13-18 Yellow Lab 5
H1 TE Monday 08-10 U56 14,18-19,21
H1 TE Monday 08-10 U14 15,17
H1 TE Monday 08-10 U133 16
H1 TL Tuesday 10-15 Yellow Lab 5
H1 TE Tuesday 15-17 U24 11,13
H1 TL Wednesday 08-13 Yellow Lab 5
H1 TE Wednesday 10-12 U157 10
H1 TE Wednesday 10-12 U155 11
H1 TE Thursday 08-10 U31 10,13,20
H2 TE Monday 10-12 U24 10-11,16,18-19,21
H2 TE Tuesday 15-17 U155 11
H2 TE Tuesday 08-10 U155 13,20
H2 TE Tuesday 10-12 U56 17
H2 TL Wednesday 13-18 Yellow Lab 5
H2 TE Wednesday 12-14 U142 15
H2 TL Thursday 13-18 Yellow Lab 5
H2 TE Thursday 14-16 U24 10,13
H2 TL Friday 10-15 Yellow Lab 5
H3 TL Monday 10-15 Yellow Lab 6
H3 TE Monday 16-18 U154 10-11
H3 TL Tuesday 13-18 Yellow Lab 6
H3 TL Wednesday 10-15 Yellow Lab 6
H3 TE Wednesday 08-10 U154 11,13,18
H3 TE Thursday 10-12 U31 10,13,15-17,19-21
H3 TE Thursday 12-14 U154 14
H4 TE Tuesday 10-12 U31 10-11,13-14,16,19
H4 TL Wednesday 15-20 Yellow Lab 6
H4 TE Wednesday 16-18 U155 13
H4 TL Thursday 10-15 Yellow Lab 6
H4 TL Friday 09-14 Yellow Lab 6
H4 TE Friday 11-13 U24 10,15,17-18,20-21
H4 TE Friday 11-13 U142 11
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Comment:
Samlæses med BMB809

Prerequisites:
None

Academic preconditions:
Content of BB501 Biology from molecule to ecosystem or FF503, and content of BMB533 Molecular biology and protein chemistry is assumed known.

The course cannot be taken by students that have passed BM114.



Course introduction
The course represents a continuation of the course BMB533 "Molecular biology and protein chemistry" and the aim is to provide a coherent understanding of the transmission and exchange of genetic information, to provide knowledge of the characteristics of biological processes at the molecular level in preferentially eukaryotes, and how these processes differ between prokaryotes and eukaryotes. Examples comprising a diverse range organisms including man will be used to illustrate cellular functions and developmental processes.

Expected learning outcome


Subject overview
The course will cover the following topics:

  1. Regulation of chromatin structure and histone modifications
  2. Transcription factors and regulation of transcription in eukaryotic genome organization and replication
  3. Methods for analysis of gene function, recombinant DNA technology, gene arrays, transgenic and knockout animals, ethical considerations
  4. Regulation of transcription in eukaryotes
  5. Posttranscriptional regulation, RNA modification, processing, splicing, catalytic RNA and nuclear-cytoplasmic transport
  6. Control of gene activity via cellular signaling (signal transduction) and integration of celluæar signaling in the control of gene expression
  7. Metabolic control at the molecular level
  8. Control of the cell cycle in eukaryote organisms
  9. Cancer at the molecular level, oncogenes, tumor suppressors, DNA damage and repair, signal transduction, hormones and receptors
Literature
  • Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter: Molecular Biology of the Cell, Edition:6th , ISBN:9780815344322.
  • Forskningsartikler udvalgt i forhold til symposier.


Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
Participation in lab work is a prerequisite for exam a. Pass/fail, internal assessment by teacher.

Assessment and marking:
  1. Approval by teacher of report on laboratory exercises. Pass/fail. 0 ECTS
  2. Written examination (4 hours) with no books, and marks according to the Danish 7 point grading system with external examinators. 10 ECTS

Reexamination in the same exam period or immediately thereafter



Expected working hours
The teaching method is based on three phase model.
Intro phase: 40 hours
Skills training phase: 39 hours, hereof:
 - Tutorials: 24 hours
 - Laboratory exercises: 15 hours

Educational activities
The 40 hours intro phase include symposia.

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.