BMB521: Metabolic regulation A (5 ECTS)

STADS: 01007201

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd quarter.

Teacher responsible
Email: nils.f@bmb.sdu.dk

Additional teachers
wuestner@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Comment:
Se i øvrigt BMB505.

Prerequisites:
None

Academic preconditions:
BMB502 Enzymes and membranes must be attended. Knowledge of BMB503 Fundamental biochemistry.

Course introduction
The course aims to give an understanding of metabolic pathways in mammalian cells and their regulation at a molecular level. Participants will gain insights into metabolic and signaling pathways that regulate glucose-, lipid- and amino acid metabolism.

Qualifications
The students will:

• get detailed an understanding of cellular processes and the regulation on a molecular level
• understand the background for the development of various metabolic diseases
• be able to collect, form, understand, and interpret results and hence understand the theoretical background • be able to give a written presentation of own observations and interpretations
• be able to orally present review articles

Expected learning outcome


Subject overview
1. Regulation of glycolysis/gluconeogenesis/TCA
2. Lipidabsorption, transport and lipoproteins
3. Fatty acid degradation
4. Fatty acid synthesis
5. Compleks lipidsynthesis
6. Amino acid metabolism
7. Signal transduction
8. Regulation of metabolism incl. glucose-fatty acid cycle
9. Integration of metabolism

The glucose-fatty acid cycle as well as integration of metabolism will be illustrated via a practical exercise/obligatory assignment

Literature

• David L. Nelson and Michael M. Cox: Lehninger Principles of Biochemistry, 5. Udgave.
• K. Frayn: Metabolic Regulation, a human perspective, 2. Udgave.
• Øvelsesvejledning.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
a) Mandatory report based on lab exercises, passed/failed, internal evaluation by teacher. The report accounts for 2 ECTS point. The report is made by three students together.
b) Two hours written examination that will be performed electronically (take home exam). The exam will be released via Black Board and the student will have 2 hours to submit the answers electronically via Black Board as a pdf or word file, graded according to the 7-point grading scale, internal examination (accounts for 3 ECTS points).

Re-examination after 4th quarter. The mode of exam at the reexamination may differ from the mode of exam at the ordinary exam.

Expected working hours
The teaching method is based on three phase model.

14 forelæsninger. 12 eksaminatorietimer/opgaveregning.
10 laboratorieøvelser/obligatorisk opgave.
Educational activities

Language
This course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.