BMB522: Molecular Biology and Human Genetic Disorders (5 ECTS)

STADS: 01002201

Level
Bachelor course

Teaching period
The course is offered in the autumn semester.
2nd quarter.

Teacher responsible
Email: ogi@bmb.sdu.dk
Email: bag@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Prerequisites:
None

Academic preconditions:
Either BM113 or BMB503 and BMB505 must be passed.

Course introduction
To give students a thorough introduction into selected genetic diseases and the molecular changes involved in them. This part is accompanied by lectures on state-of-the-art methods currently used in cell biology, enabling the students to understand the methodological background for the exploration of the various diseases etiology.

Qualifications
The students should: Part 1: Explain the basic principles and practical applications of the cell biology techniques discussed throughout the lectures. Part 2: Description of the individual diseases including knowledge of the techniques applied throughout the experiments conducted in order to elucidate the molecular mechanism.

Expected learning outcome


Subject overview
Part 1
General techniques in tissue culture, observations of live cells, biochemical/biophysical analyses of cells, - transfer of molecules into cells, labeling of proteins in intact cells, gene manipulation: transgenics
Part 2
Circadian genes- bipolar and sleeping disorders, Signaling in Alzheimer’s and related diseases, - Transmissible spongiform encephalopathies (Prion diseases), Mitochondrial diseases, Phosphoinositide signaling disorders in human disease, Disorders of lipoprotein metabolism, Cancer 1: Hormone-regulation in breast and urogenital tumors, Cancer 2: Personalized medicine – the prospects of drug-targeting signaling pathways, Cancer 3: Tumor metastasis: mechanistic insights and clinical challenges

Literature

• oplyses senere.

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Oral exam. External examiner. Danish 7 mark scale.

Date of exam
The ordinary exam takes place on January 14, 2008 and January 15, 2008

Expected working hours
The teaching method is based on three phase model.

Lectures, hours 42. Tutorials, hours 7.
Educational activities

Language
This course is taught in English.

Remarks
Part 1 is given in English. Part 2 is given in Danish or English, depending upon the participation of international students.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.