BMB528: Microbiology for Pharmaceutical Science (5 ECTS)

STADS: 01006601

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd quarter.

Teacher responsible
Email: r.p.cox@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Prerequisites:
None

Academic preconditions:
Students must have passed BB508 Biology of Animals and Plants – from Molecule to Organism and should be familiar with the material in BMB503 Fundamental Biochemistry and BMB504 Fundamental Molecular Biology. Students who have passed BM115 or BMB507 cannot participate in this course.

Course introduction
To give students in pharmaceutical science an introduction to microbiology, bacterial disease, and antibiotics.

Expected learning outcome
After completing the course, the student will be able to

• describe the structure of cells of Bacteria and Archaea and describe the biological function of the components
• describe a typical microbial growth curve and make simple calculations of growth kinetics
• describe how microbial growth is influenced by environmental factors including temperature, pH and salt
• describe the main types of energy metabolism in microbes
• describe the biochemical reactions leading to the incorporation of C and N into new cell material
• describe protein secretion and biosynthesis of extracellular structures in bacteria
• describe the exchange of genetic material between bacterial cells
• describe the properties of the major groups of Bacteria
• describe the responses of bacteria to environmental changes by differentiation and changes in behaviour
• describe host defences against microbial infections
• describe virulence factors in pathogenic bacteria
• describe the mechanism of action of selected antibiotics
• describe the mechanisms of resistance against selected antibiotics
• discuss the characteristic properties of viruses and describe viral infection of bacterial cells
• perform laboratory procedures involved in the enumeration of microbes, the isolation and characterisation of pure cultures and the study of antibiotics, and report the results in a satisfactory manner
• explain the principles of phase-contrast microscopy and use the microscope to observe bacterial cells

Subject overview
1. Cell structure.
2. Microbial growth .
3. Metabolism and biosynthesis.
4. Genetics and evolution.
5.Differentiation and behaviour
6. Microbial diversity and ecology.
7. Bacterial infection and host responses.
8. Antimicrobial compounds and antibiotic resistance.
9. Bacteriophage and other viruses.
10. Techniques for laboratory work with microorganisms.

Literature

• M. Schaechter, J.L. Ingraham, F.C .Neidhardt : Microbe, ASM Press 2006.
• Compendium to BMB507 and BMB525.

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
(a) Reports of the laboratory exercises (Pass/fail, examination by instructor only. Approved lab exercises are a prerequisite for participating in the written examination.

(b) 3 hours written examination with all aids allowed except for computers-. External examiner with grades according to the Danish 7-scale.

Reexamination after 4th quarter.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger, antal timer 24.
Eksaminatorietimer/opgaveregning, antal timer 8.
Laboratorieøvelser, antal timer 12.

Educational activities

Language
This course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.