BMB804: Molecular mechanisms of eukaryotic metabolism (5 ECTS)

STADS: 01003301

Level
Master's level course

Teaching period
The course is offered in the spring semester.
3rd quarter.

Teacher responsible
Email: nils.f@bmb.sdu.dk

Additional teachers
s.mandrup@bmb.sdu.dk
wuestner@bmb.sdu.dk
lfo@bmb.sdu.dk
bagatolli@memphys.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Prerequisites:
None

Academic preconditions:
Bachelor degree in Biochemistry, Molecular Biology, Cell Biology or Biomedicine.

Course introduction
The course has been designed to acquaint the students with the most recent advances in the field of eukaryotic metabolism. A selected set of topics is actively discussed during the course evolving around regulation of cellular lipid- and glucose homeostasis in eukaryotes.

Expected learning outcome
At the end of the course the students will be competent to:

- Describe the different experimental approaches used to decipher eukaryotic metabolism and its regulation.
- Discuss molecular mechanisms underlying metabolic regulation on a genetic, cellular and organismal level.
- Integrate diverse experimental observations into working models of metabolic pathway regulation.
- Characterize patho-biological phenotypes based on genetic or hormonal dysregulation of metabolism as well as on lipid signalling or trafficking defects.
- Explain basic concepts of modelling metabolic pathways to obtain an overall system biological view of biochemical regulation.
- Clarify the relationship between metabolic disorders like insulin resistance, diabetes or atherosclerosis and the consequence of metabolic syndrome.
- Describe new and innovative therapeutic approaches to lower cholesterol levels, avoid insulin resistance and treat obesity.

Subject overview
Genetics and regulation of lipid storage
Nutritional sensing
Mechanisms of lipid signalling
Recent advances in lipid analysis
Trafficking and lipid-related diseases
Visualization of cellular membrane dynamics
Transcriptional regulation of lipid metabolism
Impact of membrane properties on signaling and regulation
Modeling metabolic pathways in eukaryotes
Sugar and oxygen metabolism in neutrophils in diabetics
Genomics and biomedicine

Literature

Oplyses senere

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
(a) Oral exam. Pass/fail, internal evaluation by teacher.

All students are required during the course to 1) present a research article and 2) be opponents with respect to other students for being admitted to the oral exam.

Reexam after 4th quarter.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger, antal timer 12.
Eksaminatorietimer/opgaveregning, antal timer 22.
Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Remarks
Teaching will be both in danish and in english

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.