BMB804: Molecular mechanisms of eukaryotic metabolism (5 ECTS)

STADS: 01005401

Level
Master's level course

Teaching period
The course is offered in the spring semester.
3rd quarter.

Teacher responsible
Email: lfo@bmb.sdu.dk

Additional teachers
wuestner@bmb.sdu.dk
cse@bmb.sdu.dk
bagatolli@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Revison of timetable:
: Under udarbejdelse og endnu ikke endeligt.

Prerequisites:
None

Academic preconditions:
Bachelor degree in Biochemistry, Molecular Biology, Cell Biology or Biomedicine.

Course introduction
The course has been designed to acquaint the students with the most recent advances in the field of eukaryotic metabolism. A selected set of topics is actively discussed during the course evolving around regulation of cellular lipid- and glucose homeostasis in eukaryotes.

Expected learning outcome
At the end of the course the students will be competent to:

- Discuss molecular mechanisms underlying metabolic regulation on a genetic, cellular and organismal level.
- Integrate diverse experimental observations into working models of metabolic pathway regulation.
- Characterize patho-biological phenotypes based on genetic or hormonal dysregulation of metabolism as well as on lipid signalling or trafficking defects.
- Explain basic concepts of modelling metabolic pathways to obtain an overall system biological view of biochemical regulation.
- Clarify the relationship between metabolic disorders like insulin resistance, diabetes or atherosclerosis and the consequence of metabolic syndrome.
- Describe new and innovative therapeutic approaches to lower cholesterol levels, avoid insulin resistance and treat obesity.
-Use current experimental techniques to measure metabolites in eukaryotic cells.

Subject overview
- Genetics and regulation of lipid storage
- Mechanisms of lipid signalling
- Recent advances in lipid analysis
- Trafficking and lipid-related diseases
- Visualization of cellular membrane dynamics
- Transcriptional regulation of lipid metabolism
- Impact of membrane properties on signaling and regulation
- Modeling metabolic pathways in eukaryotes
- Metabolism of beta-cells
- Experimental methods to measure metabolites

Literature

• Oplyses senere.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
(a) Oral exam. Pass/fail, internal evaluation by teacher.

All students are required during the course to 1) present a research article and 2) be opponents with respect to other students for being admitted to the oral exam.

Reexam after 4th quarter.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger: 12 timer.
Eksaminatorietimer/opgaveregning: 10 timer.
Laboratorieøvelser: 14 timer
Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Remarks
Teaching will be both in danish and in english

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.