BMB804: Molecular mechanisms of eukaryotic metabolism (5 ECTS)

STADS: 01011701

Level
Master's level course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: lfo@bmb.sdu.dk

Additional teachers
wuestner@bmb.sdu.dk
cse@bmb.sdu.dk
bagatolli@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Comment:
Dele af kurset bliver undervist på engelsk.

Prerequisites:
None

Academic preconditions:
Bachelor degree in Biochemistry, Molecular Biology, Cell Biology or Biomedicine.

Course introduction
The course has been designed to acquaint the students with the most recent advances in the field of eukaryotic metabolism. A selected set of topics is actively discussed during the course evolving around regulation of cellular lipid- and glucose homeostasis in eukaryotes. In conjunction with these discussions the student will plan laboratory work to study a selected topic within glucose and lipid metabolism in collaboration with other students and a lecturer.

Expected learning outcome
At the end of the course the students will be competent to:

- Discuss molecular mechanisms underlying metabolic regulation on a genetic, cellular and organismal level.
- Integrate diverse experimental observations into working models of metabolic pathway regulation.
- Characterize patho-biological phenotypes based on genetic or hormonal dysregulation of metabolism as well as on lipid signalling or trafficking defects.
- Explain basic concepts of modelling metabolic pathways to obtain an overall system biological view of biochemical regulation.
- Clarify the relationship between metabolic disorders like insulin resistance, diabetes or atherosclerosis and the consequence of metabolic syndrome.
- Describe new and innovative therapeutic approaches to lower cholesterol levels, avoid insulin resistance and treat obesity.
-Use current experimental techniques to measure metabolites in eukaryotic cells.

Subject overview
- Regulation of lipid synthesis and storage
- Mechanisms of lipid signalling
- Recent advances in lipid analysis
- Trafficking and lipid-related diseases
- Visualization of cellular membrane dynamics
- Transcriptional regulation of lipid metabolism
- Impact of membrane properties on signaling and regulation
- Metabolism of beta-cells

Literature
There isn't any litterature for the course at the moment.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:

1. Evaluation of report of laboratory work. Grade pass/non pass, internal evaluation by teachers. (01011702)

Reexam in the same exam period or immediately thereafter.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 12 hours
Skills training phase: 22 hours, hereof:
 - Tutorials: 10 hours
 - Laboratory exercises: 12 hours

Educational activities Study phase: 16 hours

Language
This course is taught in Danish or English, depending on the lecturer. However, if international students participate, the teaching language will always be English.

Remarks
Teaching will be both in danish and in english

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.