BMB805: Molecular mechanisms in tumor biology (5 ECTS)

STADS: 01003501

Level
Master's level course

Teaching period
The course is offered in the spring semester.
4th quarter

Teacher responsible
Email: bag@bmb.sdu.dk

Additional teachers
ogi@bmb.sdu.dk
lfo@bmb.sdu.dk
bagatolli@memphys.sdu.dk
hditzel@health.sdu.dk
jmollenhauer@health.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Revison of timetable:
: Forelæsning uge 20 nu flyttet til onsdag efter ønske.
: Større lokaler
: Forelæsning uge 20 flyttet efter ønske.

Prerequisites:
None

Academic preconditions:
Bachelor degree in Biochemistry, Molecular Biology, Cell Biology or Biomedicine

Course introduction
The course has been designed to acquaint the students with the most recent advances in the field of tumor biology. A selected set of topics is actively discussed during the course to lay out many aspects, principles and laws which explain the complex behavior of human tumors.

Expected learning outcome
At the end of the course the students will be competent to analyze the following aspects related to cancer biology:

• Discuss cancer development not only as a multi step process of gene mutations but also as a result of a continuous communication between neoplastic and non-neoplastic cells and of a strict dependency on new vascularization.
• Clarify the relationship between ageing and the development and progression of cancer and discuss the genetic changes, environmental influences, host factors (e.g. oxidant stress and cell death) and differences in the manifestation of various tumor types in older and younger patients (which may help to understand tumor progression in the aging patients).
• Explain the relationship between reactive oxygen species and tumor biology and to which extent oxidants are implicated in tumor cell growth, and whether oxidative stress can be exploited therapeutically
• Describe innovative therapeutic approaches for the treatment of cancer with particular focus on specific molecular targets (i.e. ligand-inducible transcription factors) and on new liposome-based drug delivery systems

Subject overview
The role of angiogenesis in tumor development
The role of angiogenesis in tumor development
Cancer and ageing
Reactive oxygen species (ROS) in tumor biology
The concept of the magic bullet. Lipid structure and liposome applications in cancer therapy
Nuclear receptors and cancer therapy
Cancer genomics


Literature

• Oplyses senere.

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Oral exam, graded pass/fail. Internal censorship by the teacher

It is expected that all course students 1) present a scientific article, and
2) act as an opponent for other presentations, in order to apply for the oral exam.

Re-examination after 2nd quarter.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger, Antal timer 12 Eksaminatorietimer/opgaveregning, Antal timer 22
Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Remarks
Teaching will be both in danish and in english.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.