BMB807: THE SMALL RNA REGULATORS OF BACTERIA- Roles and Mechanisms in Gene Regulation (10 ECTS)

STADS: 01005001

Level
Master's level course

Teaching period
The course is offered in the autumn semester.
1st and 2nd quater

Teacher responsible
Email: valentin@bmb.sdu.dk

Timetable
Show entire timetable
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Prerequisites:
None

Academic preconditions:
None

Course introduction


Expected learning outcome


Subject overview
• The expanding universe of non-coding RNAs . The history and range of ncRNAs in bacteria
• Identification of ncRNA:
The classic phase of ncRNA discovery
The modern phase of RNA hunting -Genomic mining
• Functional classes of ncRNAs:
RNAs that modify protein activity
RNAs that modulate translation
• Molecular mechanisms / Switching on and off with ncRNA
• Requirement for a conserved RNA binding protein, Hfq – a Sm like protein
• Structure and functions of Sm proteins –key players in RNA transactions.
• The physiological role of ncRNAs in Bacteria:
Control of sugar metabolism and storage of carbon
Regulation of cell adaptation: stress-induced sRNAs
Control of alternative sigma factors: The E and S paradigms.
Control in iron metabolism
Modulators of the bacterial surface
Role of Hfq and sRNAs in virulence
• Strategies for elucidating the function and/or targets for ncRNAs
Genearrays, proteomics and computer programs
• Antisense RNA control and its biotechnological application.
• Our current picture of antisense RNA action: Unsolved problems

Literature

• Noter: Riboregulation I bakterier. .

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
a) Lab. work, pass/fail, internal examination by the teacher. Active participation in laboratory exercises are a prerequisite to pass the course.
b) Oral examination, grades according to the Danish 7-scale, external examiner.

 

Date of exam
The ordinary exam takes place on January 10, 2013
The re-examination takes place on June 28, 2013

Expected working hours
The teaching method is based on three phase model.


Educational activities

Language
No recorded information about the language used in the course.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.