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BMB807: THE SMALL RNA REGULATORS OF BACTERIA- Roles and Mechanisms in Gene Regulation (10 ECTS)

STADS: 01009101

Level
Master's level course

Teaching period
The course is offered in the autumn semester.

Teacher responsible
Email: valentin@bmb.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 08-10 U7 36
Common I Tuesday 08-10 U141 36-38
Common I Tuesday 08-10 U7 45
Common I Tuesday 10-12 U82e 46
Common I Wednesday 10-12 U35 44
Common I Wednesday 08-10 U35 47
Common I Thursday 10-12 U92 39-40
S1 TL Monday 08-18 BMB 43
S1 TE Monday 08-10 U7 45
S1 TE Monday 10-12 U82f 46
S1 TL Tuesday 08-18 BMB 43
S1 TL Wednesday 08-18 BMB 43
S1 TE Wednesday 10-12 U82f 47
S1 TL Thursday 08-18 BMB 43
S1 TL Friday 08-18 BMB 43
S1 TL Saturday 08-18 BMB 43
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Comment:
Samlæses med BMB524.

Prerequisites:
None

Academic preconditions:
None

Course introduction


Expected learning outcome


Subject overview
  • The expanding universe of non-coding RNAs . The history and range of ncRNAs in bacteria
  • Identification of ncRNA:
    The classic phase of ncRNA discovery
    The modern phase of RNA hunting -Genomic mining
  • Functional classes of ncRNAs:
    RNAs that modify protein activity
    RNAs that modulate translation
  • Molecular mechanisms / Switching on and off with ncRNA
  • Requirement for a conserved RNA binding protein, Hfq – a Sm like protein
  • Structure and functions of Sm proteins –key players in RNA transactions.
  • The physiological role of ncRNAs in Bacteria:
    Control of sugar metabolism and storage of carbon
    Regulation of cell adaptation: stress-induced sRNAs
    Control of alternative sigma factors: The E and S paradigms.
    Control in iron metabolism
    Modulators of the bacterial surface
    Role of Hfq and sRNAs in virulence
  • Strategies for elucidating the function and/or targets for ncRNAs
    Genearrays, proteomics and computer programs
  • Antisense RNA control and its biotechnological application.
  • Our current picture of antisense RNA action: Unsolved problems
Literature
  • Noter: Riboregulation I bakterier. : .


Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
  1. Lab. work, pass/fail, internal examination by the teacher. Active participation in laboratory exercises are a prerequisite to pass the course. (01008212)
  2. Oral examination, grades according to the Danish 7-scale, external examiner. (01009102)


Expected working hours
The teaching method is based on three phase model.

Forelæsninger: 20 timer
Eksaminatorietimer/opgaveregning: 5 timer
Laboratorieøvelser: 70 timer
Educational activities

Language
No recorded information about the language used in the course.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.