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BMB807: THE SMALL RNA REGULATORS OF BACTERIA- Roles and Mechanisms in Gene Regulation (10 ECTS)

STADS: 01009101

Level
Master's level course

Teaching period
The course is offered in the autumn semester.

Teacher responsible
Email: valentin@bmb.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 08-10 U7 36
Common I Tuesday 08-10 U141 36-38
Common I Tuesday 08-10 U7 45
Common I Tuesday 10-12 U82e 46
Common I Wednesday 10-12 U35 44
Common I Wednesday 08-10 U35 47
Common I Thursday 10-12 U92 39-40
S1 TL Monday 08-18 BMB 43
S1 TE Monday 08-10 U7 45
S1 TE Monday 10-12 U82f 46
S1 TL Tuesday 08-18 BMB 43
S1 TL Wednesday 08-18 BMB 43
S1 TE Wednesday 10-12 U82f 47
S1 TL Thursday 08-18 BMB 43
S1 TL Friday 08-18 BMB 43
S1 TL Saturday 08-18 BMB 43
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Prerequisites:
None

Academic preconditions:
None

Course introduction


Expected learning outcome


Subject overview
  • The expanding universe of non-coding RNAs . The history and range of ncRNAs in bacteria
  • Identification of ncRNA:
    The classic phase of ncRNA discovery
    The modern phase of RNA hunting -Genomic mining
  • Functional classes of ncRNAs:
    RNAs that modify protein activity
    RNAs that modulate translation
  • Molecular mechanisms / Switching on and off with ncRNA
  • Requirement for a conserved RNA binding protein, Hfq – a Sm like protein
  • Structure and functions of Sm proteins –key players in RNA transactions.
  • The physiological role of ncRNAs in Bacteria:
    Control of sugar metabolism and storage of carbon
    Regulation of cell adaptation: stress-induced sRNAs
    Control of alternative sigma factors: The E and S paradigms.
    Control in iron metabolism
    Modulators of the bacterial surface
    Role of Hfq and sRNAs in virulence
  • Strategies for elucidating the function and/or targets for ncRNAs
    Genearrays, proteomics and computer programs
  • Antisense RNA control and its biotechnological application.
  • Our current picture of antisense RNA action: Unsolved problems
Literature
  • Noter: Riboregulation I bakterier. : .


Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
  1. Lab. work, pass/fail, internal examination by the teacher. Active participation in laboratory exercises are a prerequisite to pass the course. (01008212)
  2. Oral examination, grades according to the Danish 7-scale, external examiner. (01009102)


Date of exam
The ordinary exam takes place on January 27, 2014
The re-examination takes place on February 25, 2014

Expected working hours
The teaching method is based on three phase model.


Educational activities

Language
No recorded information about the language used in the course.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.