BMB813: Mechanisms of Eukaryotic Cell Signalling and Cell Differentiation (5 ECTS)

STADS: 01006301

Level
Master's level course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: bab@bmb.sdu.dk

Additional teachers
jens.andersen@bmb.sdu.dk

Timetable
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Prerequisites:
None

Academic preconditions:
For SDU students: BM113 or BMB503 Fundamental Biochemistry & BMB505 Metabolic regulation must be passed.

Course introduction
To give students a thorough introduction to signalling events which underlie eukaryote cell function and dysfunction. Mechanism by which extracellular signals are transmitted to cells and exert their effects will be discussed. Principles of stem cell differentiation involving various signalling networks will be disscussed as well. Participants will learn about the roles of signalling molecules such as hormones, receptors, kinases, and transcription factors. Participants will also gain experience in reading original research articles and in oral and written presentation of scientifc results.

Expected learning outcome


Subject overview
• Principles of signalling networks
• Growth factor signalling and its involvement in cancer
• PI3K-signalling
• Transforming growth factor beta (TGF-beta) signalling
• Stem cell differentiation
• Proteomics approahes to cell signalling and systems biology

 

Literature

• Harvey Lodish: Molecular Cell Biology, W.H. Freeman.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Students will give short presentations of original research articles. Students are expected to attend at least 80% of the scheduled hours and participate actively in discussions following the presentations. There will be a short assignment from the computer exercises, which should be passed to qualify for the exam. The assignments are evaluated internally by the teacher and instructor with pass/fail.
They will also prepare a short synopsis about a signaling topic as an individually written report. Instructors will advise in the preparation of this synopsis, which will also be the basis for the course grade according to the Danish 7-point scale with an external examiner.

Reexam after 4th quarter

Expected working hours
The teaching method is based on three phase model.

Forelæsninger (12 timer), studenterpræsentationer (8 timer), eksaminatorietimer og laboratorieøvelser (16 timer).
Educational activities

Language
This course is taught in English.

Remarks
The course is designed for master students. Minimum 10 students are required to hold the course. The course is limited to 18 participants.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
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