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BMB835: Cancer Cell Biologi (10 ECTS)

STADS: 01015701

Level
Master's level course

Teaching period
The course is offered in the spring semester.

Teacher responsible

Email: bag@bmb.sdu.dk

Additional teachers

belcheva@bmb.sdu.dk

Timetable

Group	Type	Day	Time	Classroom	Weeks
Common	I	Monday	14-16	U12	6
Common	I	Tuesday	08-10	U145	7
Common	I	Tuesday	08-10	U153	8-9
Common	I	Wednesday	08-10	U143	6
Common	I	Wednesday	09-11	U103	8
Common	I	Wednesday	09-11	U10	9
Common	I	Thursday	08-10	U10	5
Common	I	Thursday	13-15	U59	7
Common	I	Friday	08-10	U143	5
H1	TL	Monday	08-16	Blue Lab	10
H1	TL	Tuesday	08-16	Blue Lab	10
H1	TL	Wednesday	08-16	Blue Lab	10
H1	TL	Thursday	08-16	Blue Lab	10
H1	TL	Friday	08-16	Blue Lab	10

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Comment:
Min. 5 deltagere og maks. 20 deltagere Dette kursus undervises på dansk eller engelsk, afhængigt af underviseren. Dog altid på engelsk ved deltagelse af internationale studerende. Dette øvelseskursus udføres ifølge lovmæssige sikkerhedsanvisninger, men anvender eksperimentelle protokoller og kemikalier som er mistænkt for at være potentielt skadelige for gravide/ammende. Gravide/ammende studerende bør derfor kontakte kursusansvarlig i god tid før kursustilmelding.

Prerequisites:
Bachelor degree in BMB or Biomedicine

Academic preconditions:

Students taking the course are expected to:

Have fundamental knowledge of cell biology and molecular biology
Be able to use basic techniques within the area of cell biology and molecular biology.

Course introduction

The aim of the course is to provide extensive knowledge on the molecular and cell biology of cancer. The first part of the course gives a detailed overview of the factors and mechanisms that contribute to the development of this disease while the second part focuses on specific types of cancer highlighting similarities and differences.

It is the goal of the course to strengthen the specific academic profile of the students within the area of Biomedicine and Biochemistry/Molecular Biology.

The course establish a logical connection with some of the courses followed earlier in the area of BMB and Biomedicine and bring the students to an upper-level knowledge and expertise expanding specific skills and competence with which they have familiarized earlier. An intensive practical training gives the students the possibility to put into practice the theory they have been learning follows the theoretical part of the course.

The course builds on the knowledge acquired in the Bachelor degree in BMB/Biomedicine and gives an academic basis for studying topics cancer cell biology – typically in a masters project.

In relation to the competence profile of the degree it is the explicit focus of the course to make the students able to:

Describe and explain relevant concepts related to the biology of cancer
Develop and formulate constructive criticism on peer-reviewed articles
Understand how scientific knowledge is acquired by an interplay between theory and experiments
Muster modern techniques in the fields of Cell Biology, Biochemistry and Molecular Biology
Formulate a critical assessment of the results obtained relating them to each other

Expected learning outcome

The learning objective of the course is that the student demonstrates the ability to:

Part 1:

Understand and use appropriately the terminology within the cancer cell biology field
Understand the nature of cancer and cell processes leading to uncontrolled cell proliferation
Explain the molecular and cellular basis of frequently occurring forms of cancer
Analyse molecular and cellular aspects of rare forms of cancer
Discuss the most common types of childhood cancers and the major differences between cancers in adults and children

Part 2:

Design a strategy for the cloning of cDNA into mammalian expression plasmids for the expression of a recombinant tumour suppressor protein in mammalian cells
Elucidate the intracellular regulation of a tumour suppressor gene product
Analyse the role of tumour suppressor proteins as master guardian of the genome

Subject overview

The following main topics are contained in the course:

Molecular mechanisms in cell cycle regulation
The biology and genetics of cancer
The role of oncogenes and tumour suppressor genes
Cell signalling
Maintenance of genomic integrity and cancer development
Tumour angiogenesis
Tumour metastasis
The rational treatment of cancer
Molecular and cellular features of cancers of the central nervous system, pancreatic cancer, skin cancer, gastrointestinal tract malignancies, blood cell cancers, germ cell tumours, rare forms of cancer, cancers of childhood

Literature
There isn't any litterature for the course at the moment.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:

Written report based on lab. work. The report is submitted as group work. (5 ECTS). Passed/Failed. Internal evaluation by the teachers. Exam aids allowed. (01015712).
Written exam (multiple choice questions) 2 hrs w/o aids. (5 ECTS). Internal evaluation by the teachers. Grades according to the Danish 7-point scale. No exam aids allowed. (01015702).

Expected working hours
The teaching method is based on three phase model.
Intro phase: 20 hours
Skills training phase: 50 hours, hereof:
- Laboratory exercises: 50 hours

Educational activities

To read and study text-book chapters, scientific articles and websites which should complement the content the lecture slides
To prepare for the practical part of the course
To write an obligatory report

Educational form

The intro-phase comprises lectures, which will be carried out in the form of a dialog between the teachers and the students. The lectures will cover relevant topics that are part of the course and will supply the selected literature with additional notions and perspectivation. The lecture slides will, in fact, contain information that is not necessarily part of the assigned literature. The relevant theory for carrying out the practical part of the course will be discussed during the lectures.

In the training phase, the students will have the opportunity to apply the acquired knowledge by performing experiments related to some of the topics discussed during the lectures. The students will be acquainted with modern techniques in the fields of Molecular Biology, Biochemistry and Cell Biology. In the study phase, the students are expected to re-elaborate the knowledge acquired during the lectures and the practical part of the course with the help of the selected literature. The lectures and laboratory training are meant to complement each other and provide the students with optimal learning tools.

Language
This course is taught in Danish or English, depending on the lecturer. However, if international students participate, the teaching language will always be English.

Remarks
The course can not be chosen by students who have taken BMB810.
The course cannot be chosen by students who: are not enrolled in BMB or Biomedicine.

The course has limited seats and in case of too many applications, priority is given to the timely registration by date of registration.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.