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FA808: Advanced drug formulation (5 ECTS)

STADS: 3855501

Level
Master's level course

Teaching period
The course is offered in the autumn semester.

Teacher responsible

Email: kuntsche@sdu.dk

Timetable

Group	Type	Day	Time	Classroom	Weeks
Common	I	Wednesday	08-10	U146	46
Common	I	Wednesday	10-12	U154	47
Common	I	Thursday	08-10	U154	46
H1	TE	Wednesday	10-14	*Odense Lokalitet aftales 10	1
H1	TE	Wednesday	09-15	*Odense Lokalitet aftales 10	2
H1	TE	Wednesday	10-12	U154	46
H1	TE	Wednesday	12-14	U30	47
H1	TL	Wednesday	09-12	Lab 10	48,50-51
H1	TL	Wednesday	13-16	Lab 10	48,50-51
H1	TE	Wednesday	12-16	U30	49
H1	TE	Thursday	08-10	U156	47
H1	TE	Thursday	08-10	U154	49

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Prerequisites:
The courses Drug formulation and production (FA502, FA503 and FA504) at bachelor pharmacy must be passed.

Academic preconditions:
The Drug Transport and Drug Delivery Systems should have been followed.

Course introduction
The aim of the course is to deepen theoretical and experimental aspects of modern advanced drug formulation to optimize the therapeutic efficiency of drug therapy. The course will provide the students and deeper understanding of advanced formulation strategies with respect on both formulation development and marketed medicines.

The aim of the course is to deepen theoretical and experimental aspects of modern advanced drug formulation to optimize the therapeutic efficiency of drug therapy. The course will provide the students and deeper understanding of advanced formulation strategies with respect on both formulation development and marketed medicines. The course will thus contribute providing the students with competences which are needed for a pharmacist to perform in the area of drug formulation development as well as consulting clinical professionals on new medicines.

The course builds on the knowledge acquired during the bachelor in pharmacy (especially courses in Drug Formulation and Production [FA 502, FA 503 and FA 504] and the course Drug Transport and Drug Delivery Systems at master level.

In relation to the competence profile, the explicit focus of the course is:

to provide knowledge and understanding of advanced drug formulation for at optimize the therapeutic efficiency of drug therapy, especially focusing on improvement bioavailability after oral administration, controlled drug release and drug targeting.
to train skills in manufacturing and characterization of advanced dosage forms (such as nano- and microparticulate dispersions, self-emulsifying formulations, solid dispersions), in searching and evaluation of scientific literature and in discussing professional issues.
to provide competences in critical and problem-oriented assessment and discussion of advanced dosage forms with respect on both formulation development and marketed medicines.

Expected learning outcome

The learning objectives of the course is that the student demonstrates the ability:

to apply relevant physicochemical terms and principles in drug formulation
to explain relevant biopharmaceutical and therapeutic questions in relation to drug formulation
to use relevant databases for searching the scientific literature and professional information
to discuss marketed advanced medicines and advanced formulation principles in drug development
to analyze and discuss experimental results
to present theoretical contexts and experimental results in both oral and written form

Subject overview

The following main topics are included in the course:

parenteral depot formulations (microparticles, in-situ forming implants)
nanoparticulate drug formulations for intravenous administration (liposomes, fat emulsions, nanoparticles) incl. drug targeting principles
formulation principles of oral medicines with improved bioavailability of critical drug compounds (self-emulsifying formulations, solid dispersions and nanocrystals)
formulation and manufacturing principles of selected above-mentioned drug formulations
selected analytical methods to characterize the above-mentioned drug formulations (such as microscopy, UV/Vis spectroscopy, particle size analysis, X-ray diffraction, thermal analysis)

Literature

P.J. Sinko: Martin’s Physical Pharmacy and Pharmaceutical Sciences, 7th edition, Wolters Kluwer.
Yderligere undervisningsmaterialer lægges på E-Learn.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:

Expected working hours
The teaching method is based on three phase model.
Intro phase: 6 hours
Skills training phase: 40 hours, hereof:
- Tutorials: 22 hours
- Laboratory exercises: 18 hours

Educational activities

self-study and after work of topics from the lectures
literature search and evaluation
analysis of results from the laboratory exercises
preparation of a presentation of a selected topic
report writing

Educational form

The intro phase consists of lectures providing a short introduction into the central topics of the course.

The training phase provides competences within the central topics of the course. During the seminars, the students will work in small groups on a selected topic (theoretical project) and results of the laboratory exercises will be discussed. I the lab exercises, selected experiments and tests within the central topics of course will be performed.

During the study phase, the students will independently work with the literature to obtain and deepen the central topics of the course. Moreover, the students will recapitulate the tasks from the training phase (writing of reports, work on the theoretical projects) and prepare the final presentation of the theoretical project.

Language
This course is taught in Danish or English, depending on the lecturer.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.