KE506: Synthesis (5 ECTS)

STADS: 10012401

Level
Bachelor course

Teaching period
The course is offered in the autumn semester.
The course is held in August

Teacher responsible
Email: joj@sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Prerequisites:
None.

Academic preconditions:
Students who attend the course are expected to

• have knowledge of general chemistry and systematic organic chemistry including organic structure and reactions.
• be able to apply organic reaction mechanisms
• have practical experience with laboratory work including basic organic synthesis and general laboratory safety in a synthesis laboratory.

Course introduction
The aim of the course is to give the students a detailed knowledge about unit operations used in a synthetic laboratory. Thus, the objective of the course is to provide the students with practical knowledge that forms the basis of the completion of a bachelor project within synthetic chemistry and for further studies.

The course is based primarily on the skills acquired in the second year course KE505 or equivalent with a systematic treatment of organic chemistry. The course is based on the fact that the students are in the third or fourth year of studies for a degree in chemistry, nanobioscience, pharmacy, or chemical engineering, so that they can relate the course to other disciplines in chemistry, for example spectroscopy, chemical engineering, physical chemistry, or inorganic chemistry.

In relation to the education competence profiles, the course has a particular focus on expanding and improving the experimental basis for chemical synthesis including the handling of safety aspects in an organic synthesis laboratory.

Expected learning outcome
The learning objectives of the course is that the student demonstrates the ability to:

• relate theoretical knowledge of organic reactions and reaction mechanisms to carry out practical organic synthesis
• carry out synthesis
• carry out limited multi-step syntheses
• carry out synthesis under an inert atmosphere
• describe and use different purification techniques
• determine the purity of the compounds synthesized using analytical and spectroscopic methods
• conduct literature searches in Reaxys
• explain and apply safe behavior in a synthetic laboratory

Subject overview
The following main topics are contained in the course:

• Precautions against accidents in the laboratory
• Secure behavior in a synthetic laboratory
• Literature search in Reaxys
• Planning of synthetic work
• Different unit operations used in a synthetic laboratory
• Preparation of selected organic and inorganic compounds
• Safe behavior in a synthetic laboratory

Literature

• Mikael Begtrup, Jan Becher og Mogens Brøndsted: Håndbog i organisk synteseteknik, Gyldendal, 2011.
• Jan O. Jeppesen, Stinne W. Hansen, Steffen Bähring, Niels Svenstrup & Jesper Lau: Institut for Fysik og Kemi, Syddansk Universitet, 2010.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam

1. Attendance at laboratory exercises and approval of compulsory reports with theoretical questions. Pass/fail, internal marking by teacher.

Assessment and marking:

1. Oral exam with internal evaluation and marks according to the Danish 7-point marking scale. At the exam, the student should present a PowerPoint presentation. (5 ECTS). (10012402).

Re-examination right after the end of the course.

Expected working hours
The teaching method is based on three phase model.
Skills training phase: 48 hours, hereof:
 - Laboratory exercises: 48 hours

I studiefasen forventes de studerende at arbejde med selvstudium af lærebogen og eksempler heri. Derudover indgår laboratorierapporter og rapportskemaer som centrale elementer i studiefasen, og de studerende kan forvente feedback fra en underviser på begge dele. De studerende forventes også at bruge en del af studiefasen på at samle op på træningsfasens indhold samt at reservere en mindre del til repetition op til den mundtlige eksamenSkills training phase: 48 hours, hereof:
 - Laboratory exercises: 48 hours

Educational activities

Educational form
In the study phase, students are expected to work on their own with the textbook and examples herein. It also includes both laboratory reports and report schemes as key elements in the study phase, and students can expect feedback from a teacher at both. The students are also expected to use part of the study phase to pick up on the content of training phase and to reserve a small amount of time for repetition for the oral exam.

Language
This course is taught in Danish or English, depending on the lecturer. However, if international students participate, the teaching language will always be English.

Remarks
The course has a limited number seats. For chemistry students, who follows the course mandatory, are garanteed a seat.
If there are vacant seats they will be assigned after:

1. Graduate students in medical chemistry, who are following the course in their module A
2. Students who have passed KE505

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.