KE805: Supramolecular and nanochemistry (5 ECTS)

STADS: 10003001

Level
Master's level course

Teaching period
The course is offered in the autumn semester.

Teacher responsible
Email: snv@sdu.dk

Timetable
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Prerequisites:
Bachelor´s degree in pharmacy or nanobioscience must be passed. Or B.Sc. minor degree in chemistry.

Academic preconditions:
Students taking the course are expected to:

• Have knowledge of general chemistry, basic spectroscopy and organic chemistry
• Be able to use basic principles of physical chemistry

Course introduction
The aim of the course is to enable the student to combine theoretical knowledge on non-covalent interactions with design rules of host-guest systems as well as function and design of molecular devices, to choose classical and modern synthetic routes for the synthesis molecular receptors and building blocks of molecular devices, to acquire comprehensive knowledge on common molecular building blocks in supramolecular chemistry and their application, to rationalize basic design rules for molecular receptors and molecular devices, to achieve an overview and apply modern analytical tools to supramolecular systems, to apply search strategies for current databases and electronic journals to find relevant information on supramolecular systems as well as to orally present and analyse articles from the field of supramolecular chemistry. The acquired knowledge is important to be able to apply basic concepts from physics, general chemistry, organic chemistry and spectroscopy to a broad range of applied and fundamental supramolecular questions.

At the end of the course, students are expected to suggest solutions to synthetic challenges and questions in connection with molecular design for a wide variety of applications and challenges in supramolecular chemistry.

The course builds on the knowledge acquired in the bachelor courses in physics, chemistry, pharmacy and nanobioscience, and gives an academic basis for studying the topics such as drug delivery, advanced organic materials, molecular diagnostics, and nucleic acid technology, that are part of the master degree.

In relation to the competence profile of the degree it is the explicit focus of the course to:

• Give the competence to molecular design in supramolecular chemistry
• Give skills in synthesis and application of supramolecular systems with applications in material science, medicinal chemistry and molecular diagnostics
• Give knowledge and understanding of important non-covalent forces and their application in supramolecular chemistry

Expected learning outcome
The learning objectives of the course is that the student demonstrates the ability to:

• Understand and use non-covalent interactions
• Understand and apply synthetic methods such as template-controlled reactions for the synthesis of supramolecular building blocks
• Acquire knowledge on important building blocks in supramolecular chemistry
• Apply non-covalent interactions in molecular design
• Apply supramolecular building blocks and molecular design to modern challenges in supramolecular chemistry

Subject overview
The following main topics are contained in the course:

• Non-covalent interactions
• Molecular receptors (e.g. for cations, anions and neutral molecules)
• Supramolecular building blocks (e.g. macrocycles, DNA, peptides, nanoparticles)
• Applications of supramolecular chemistry for molecular diagnostics, material science and medicinal chemistry
• Synthetic methods in supramolecular chemistry

Literature

• Jonathan W. Steed, Jerry L. Atwood: Supramolecular chemistry, 2nd ed. / Wiley 2009.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:

1. Oral exam. Danish 7 mark scale, external examiner. Allowed IT-tools: Notebook.

Reexamination in the same exam period or immediately thereafter. The mode of exam at the reexamination may differ from the mode of exam at the ordinary exam.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 10 hours
Skills training phase: 40 hours, hereof:
 - Tutorials: 40 hours

Educational activities
Activities during the study phase:

• Preparation of student lectures based on current literature in supramolecular chemistry
• Group discussions of individual student presentations in plenum

Educational form

Language
This course is taught in English.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.