KE811: Advanced NMR spectroscopy (5 ECTS)

STADS: 10003501

Level
Master's level course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: mip@sdu.dk

Additional teachers
ugn@sdu.dk
pcs@sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Comment:
Resterende timer aftales med de studerende.

Prerequisites:
None

Academic preconditions:
Bachelor’s degree in Chemistry, Pharmaceutical Sciences, Nanobioscience or Chemical Engineering, or minor in Chemistry. The NMR part of KE811 Spectroscopy and structural chemistry should be attended.

Course introduction
To apply NMR techniques to determine the structure of a.o. small molecules and biological macromolecules.

Expected learning outcome
At the end of the course the students should be able to:

• perspectivate common solid-state and solution NMR experiments (HNMR, CNMR, DEPT, INEPT, HETCOR, HSQC, HMQC, COSY, DQCOSY, INADEQUATE, NOESY, NOE-difference, CP, MAS) and discuss their application to structure determination.
• solve the Bloch-equations and employ these to explain NMR experiments by means of the vector model.
• discuss scalar-, dipolar- and quadrupolar interactions and their influence on the position, intensity, splitting and width of the lines in an NMR spectrum as well as relaxation times and NOE.
• apply the notion of chemical shift and employ chemical shifts to determine the stereo structure of a molecule. Calculate chemical shifts in order to differentiate between possible structures.
• use intensities in HNMR and CNMR and perspectivate factors that influence those (number of nuclei, NOE, relaxation times, exchange)
• analyze spin-spin couplings and use first order spin-spin analysis in order to determine the stereo structure of a molecule.
• Analyze second order effects and employ the concepts chemical and magnetic equivalence.
• recognize the influence the dynamics of a molecule has on the NMR line width.

Subject overview
NMR spectroscopy

Literature

• Horst Friebolin: Basic One- and Two-Dimensional NMR Spectroscopy, Wiley-VCH. Noter.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:

1. a) Exercises which are evaluated collectively, passed/failed, internal censorship by the teacher.

Reexamination in the same exam period or immediately thereafter.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 7 hours
Skills training phase: 43 hours, hereof:
 - Tutorials: 7 hours
 - Laboratory exercises: 36 hours

Educational activities

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.