KE811: Advanced NMR spectroscopy (5 ECTS)

STADS: 10003501

Level
Master's level course approved as PhD course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: pcs@sdu.dk

Additional teachers
ugn@sdu.dk
mip@sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Prerequisites:
Bachelor’s degree in Chemistry, Pharmaceutical Sciences, Nanobioscience or Chemical Engineering, or minor in Chemistry.

Academic preconditions:
Students taking the course are expected to:

• be able to apply NMR spectroscopy as an analytical tool
• know the theoretical basis for NMR spectroscopy and quantum chemistry
• possess fundamental math skills
• KE826 Spectroscopy should be attended before the course.

Course introduction
The aim of the course is to give students a theoretical understanding of NMR spectroscopy and to show applications within NMR spectroscopy.

The course builds on the knowledge acquired in a course on analytical spectroscopy, e.g. KE504, in basic math and quantum chemistry courses and besides this knowledge of the basics of NMR theory, e.g. KE826.

The course will show various applications of NMR spectroscopy and hence afford students with knowledge of detailed state-of-art applications of NMR.

In relation to the competence profile of the degree it is the explicit focus of the course to give students the ability to apply NMR spectroscopy in structural characterisation in a broad sense. 

Expected learning outcome
At the end of the course the students should be able to:

• perspectivate common solid-state and solution NMR experiments (HNMR, CNMR, DEPT, INEPT, HETCOR, HSQC, HMQC, COSY, DQCOSY, INADEQUATE, NOESY, NOE-difference, CP, MAS) and discuss their application to structure determination.
• solve the Bloch-equations and employ these to explain NMR experiments by means of the vector model.
• discuss scalar-, dipolar- and quadrupolar interactions and their influence on the position, intensity, splitting and width of the lines in an NMR spectrum as well as relaxation times and NOE.
• apply the notion of chemical shift and employ chemical shifts to determine the stereo structure of a molecule. 
• calculate chemical shifts in order to differentiate between possible structures.
• use intensities in HNMR and CNMR and perspectivate factors that influence those (number of nuclei, NOE, relaxation times, exchange)
• analyze spin-spin couplings and use first order spin-spin analysis in order to determine the stereo structure of a molecule.
• analyze second order effects and employ the concepts chemical and magnetic equivalence.

Subject overview


Literature

• Horst Friebolin: Basic One- and Two- Dimensional NMR Spectroscopy, Wiley-VCH. Noter.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:


Expected working hours
The teaching method is based on three phase model.
Intro phase: 7 hours
Skills training phase: 43 hours, hereof:
 - Tutorials: 7 hours
 - Laboratory exercises: 36 hours

Educational activities

• Working with reports

Educational form

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.