KE822: Organic chemical analysis and separation (5 ECTS)

STADS: 10010401

Level
Master's level course

Teaching period
The course is offered in the autumn semester.
The course takes place in the second part of the autumn semester.

Teacher responsible
Email: joj@sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Comment:
Samlæses med KE510

Prerequisites:
The course cannot be chosen by students who passed KE510: Organic chemical analyses and separation.

Academic preconditions:
Students taking the course are expected to:

• have knowledge of NMR and IR spectroscopy and mass spectrometry.
• have detailed knowledge of organic chemistry, especially organic molecular structure and chemical reactions.
• have knowledge of simple inorganic molecules and salts as well as pH concept.
• have practical experience with laboratory work and general laboratory safety.

Course introduction
The aim of the course is to be trained in laboratory skills in organic chemistry, especially for workup and identification of organic compounds. The course forms therewith a basis for further chemistry and pharmacy courses and for experimental work within organic chemistry, medicinal chemistry or pharmacy. Furthermore, it forms the course background for pharmacy students to continue studies in medicinal chemistry and drug development, for chemistry students’ further study in organic synthesis and materials chemistry, and chemical engineering students’ further studies in process engineering.

The course builds on the knowledge acquired in the first-year course FF503 or equivalent with a basic level of general and organic chemistry and subsequent courses in organic chemistry KE505 and spectroscopy KE504. The course is based on the fact that the students are in the fourth year of studies for a degree in chemistry, pharmacy or chemical engineering, so that they can relate the course to other disciplines in chemistry, for example biochemistry, spectroscopy, chemical engineering, physical chemistry or inorganic chemistry.

In relation to the competence profile of the degree it is the explicit focus of the course to:

• Give authority to plan organic chemical laboratory work.
• Provide skills in identification of organic compounds.
• Provide skills and knowledge about the methods of separation of organic compounds.
• Provide skills in performing chemical synthesis on a small scale.
• Provide knowledge about the handling of the security aspects in an organic chemistry lab.

Expected learning outcome
The learning objectives of the course is that the student demonstrates the ability to:

• Use chemical methods for identification of organic compounds.
• Use spectroscopic methods for identification of organic compounds.
• Use chemical and column chromatographic separation techniques
• Perform chemical reactions on a small scale.
• Find reference data online.
• Using gas chromatography and HPLC.
• Estimate purity of a chemical.

Subject overview
The following main topics are contained in the course:

• Separation of substance mixtures by extraction and preparative column chromatography.
• Making derivatives of organic compounds.
• Determination of functional groups and equivalent.
• HPLC and GLC analysis.
• Identification by MS, 1H and 13C NMR and IR spectra.

Literature

• Øvelsesvejledning, der placeres på Blackboard..

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam

1. Active participation in laboratory exercises and approval of two reports. Pass/fail, internal marking by teacher. (10010412).

Assessment and marking:

1. Written report. Graded according to the Danish 7-mark scale. External marking. (5 ECTS). (10010402).

A closer description of the exam rules will be posted under 'Course Information' on Blackboard.

The mode of examination at the reexamination may differ from the mode of exam at the ordinary examination.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 1 hours
Skills training phase: 49 hours, hereof:
 - Laboratory exercises: 49 hours

Educational activities

Educational form
Activities during the study phase:

• Self-study of methods for organic identification.
• Tutorial of electronic programs for literature search and handling of NMR and MS data.
• Identification of organic compounds on the basis of collected data.
• Preparation of reports of laboratory work and the identified organic compounds.

Language
This course is taught in English, if international students participate. Otherwise the course is taught in Danish.

Remarks
The course has a limited number of seats. 
If there are vacant seats they will be assigned after these principles:

1. Graduate students in medical chemistry, who are following the course in their module A
2. Students who have passed KE505

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.