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KE828: Medicinal chemistry B (5 ECTS)

STADS: 10010701

Level
Master's level course

Teaching period
The course is offered in the autumn semester.

Teacher responsible
Email: elc@sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 14-16 U57 2 Spørgetime - KE828
Common I Monday 12-14 U17 36
Common I Monday 10-12 U24A 37
Common I Monday 10-12 U49D 39
Common I Monday 10-12 U51 40
Common I Monday 12-13 U141 41
Common I Monday 12-14 U23A 43
Common I Monday 10-12 5.3.32 A 44
Common I Monday 10-12 U17 46,48
Common I Thursday 10-12 U142 37
Common I Thursday 10-12 U23A 40
Common I Thursday 08-10 U17 43
Common I Friday 14-16 U155 36 Velkommen-til-kandidaten på FKF
Common I Friday 12-14 U105 45,47
H1 TE Tuesday 16-18 U21 49
H1 TE Thursday 12-14 U141 37
H1 TE Thursday 12-14 U31 39
H1 TE Thursday 12-14 *Odense Lokalitet aftales 10 40
H1 TE Thursday 10-12 U49C 43
H1 TE Thursday 08-10 U21 45-46
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Prerequisites:
None

Academic preconditions:
KE511 Medicinal chemistry assumed known.

Course introduction
The objective of the course is to give the students knowlegde on the effect of physico-chemical properties of a drug on the pharmacokinetic properties. The course is an extention of medicinal chemistry A and will focus on ADMET properties, optimization strategies and case studies.

Qualifications
The student will be able to:

  • Perform rational drug design with consideration to physico-chemical properties including the use of physico-chemical descriptors and target-ligand interactions.
  • Know different drug design optimization strategies including fragment based drug design, pharmacophore modeling and to relate to medicinal chemistry articles and ADMET data.
Expected learning outcome
After the course the student is expected to be able to:

  • Explain the effect of physico-chemical properties on drugs ADMET properties.
  • Explain and discuss different optimization strategies of physico-chemical properties including the use of physico-chemical decripters.
  • Explain target-ligand interactions and methods for optimization of these.
  • Discuss medicinal chemistry articles containing ADMET data.
Subject overview
Physico-chemical properties (pKa, lipophilicity, solubility, ect.) ADMET, optimization strategies, target-ligand interactions, fragment based drug design, modeling in medicinal chemistry (pharmacophores, homology models, docking, in silico screening).

Literature
There isn't any litterature for the course at the moment.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
4 electronic tests. Internal evaluation by teacher, pass/fail.

Assessment and marking:
Oral examination. External evaluation, Danish 7-mark scale. Reexam in February.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 28 hours
Skills training phase: 14 hours, hereof:
 - Tutorials: 14 hours

Educational activities

Language
This course is taught in Danish or English, depending on the lecturer. However, if international students participate, the teaching language will always be English.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.