BMB501: Biomolecular Chemistry (5 ECTS)

STADS: 01000101

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd quarter.

Teacher responsible
Email: f.kir@bmb.sdu.dk

Additional teachers
ebp@ifk.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Revison of timetable:
: Skemaændringer S6 efter ønske.
: Hold S6 flyttet fredage i ugerne 09-11 efter ønske.
: Forelæsning samt S1 og S9 flyttet onsdag uge 9.
: S8 og S18 er sammenlagt i BMB501 lab i uge 9.

Comment:
I umiddelbar forlængelse af forelæsningen i BMB501 i U55 vil repræsentanter fra de forskellige institutter guide jer videre til de forskellige mødesteder.:

BIOMEDICIN BIOKEMI & MOLEKYLÆR BIOLOGI:
(Opsamling I U55 eller mødested BMB´s seminarrum)
MATEMATIK ANVENDT MATEMATIK
(Mødested U49B)
FYSIK
(Opsamling I U55 eller mødested i MEMPHYS common room)
NANOBIOSCIENCE
(Mødested: Foran U55)
KEMI
(Opsamling I U55 eller mødested: Spektroskopilokalet)


Prerequisites:
None

Academic preconditions:
Students should be familiar with KE501 – Fundamental chemistry and BB501 – Biology from molecule to ecosystem or BB508 – Animal and plant biology. Students that have passed BM102 cannot follow BMB501.

Course introduction
The aim of the course is to give the student an understanding of biomolecules in both chemical and biological contexts by

• Introducing the central types of biological macromolecules: proteins, nucleic acids carbohydrates and lipids.
• Demonstrating that fundamental organic chemistry defines the structure and thereby the function of these biological macromolecules.
• Illustrating that the function of biological macromolecules is normally of fundamental organic chemical nature.

Qualifications
• Ability to assess the significance of fundamental chemical properties on biomolecular structure. • Understanding of the connection between biomolecular structure and function. • Knowledge of chemical synthesis of biomolecules and the chemical reactions of biomolecules. • Fundamental skills in a biochemistry laboratory; incl. handling of microlitre volumes, reproduction of experiments and conducting experiments base on a written instructions.

Expected learning outcome
The student is expected to be able to do the following when the theoretical part of the coursed is passed:

• Name and outline mechanisms for the non-covalent forces that operate on biomolecules
• Discuss the four structure levels of proteins
• Explain the significance of hydrophobic and hydrophilic forces for the structure of biomolecules and give examples thereof.
• Explain the significance of steric effects for the structure of biomolecules and give examples thereof.
• Outline and exemplify the relation between structure and function of biomolecules
• Draw the basic structure of carbohydrates, nucleic acids, peptides/proteins and lipids.
• Name the functional groups in carbohydrates, nucleic acids, peptides/proteins and lipids.
• Name heterocyclic rings.
• Sketch common chemical and enzymatic reactions for the above mentioned functional groups and heterocyclic rings.
• Be familiar with the principles in chemical syntheses of nucleic acids and peptides.
• Use nomenclature from stereochemistry on biomolecules.
• Sketch biomolecules and heterocyclic rings at various pH values.

The student is expected to be able to do the following when the laboratory part of the coursed is passed:

• Handle adjustable micro pipettes in a reproducible manner
• Make dilution series and measure these spectrophotometrically
• Have knowledge about gel electrophoresis
• Outline the principles in spectrophotometrical measurements, and be familiar with the use of a spectrophotometer in studies of biochemical reactions.
• Be familiar with the use of standard curves.
• Carry out an enzymatic synthesis.
• Have knowledge about measuring optical purity of a chemical substance.

Subject overview
1. Carbohydrates:

• Monosaccharides and their stereochemistry
• Disaccharides
• Polysaccharides and their biological differences.
  
  

2. Nucleic acids:

• Nucleosides and heterocyclic chemistry, including tautomerisation
• Nucleotides
• Oligonucleotides and their synthesis
• DNA/RNA structure
  
  

3. Peptider:

• Amino acids and their organic chemistry
• Peptides; their synthesis and structural properties
• Protein structure and function.
• Protein-nucleic acid recognition
  
  

4. Lipids:

• Structure
• Hydrophobic and hydrophilic properties
• Lipids and proteins in membranes

Literature

• Kirpekar & Pedersen: Biomolecular Chemistry, 3rd edition., Pearson Custom Publishing. Kan købes i Studenterboghandelen .

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
(a) Approved laboratory results, fail/pass, internal assessment by instructor. The lab exercises constitute 1 ECTS of the total 5 ECTS of the course.
(b) 4-hour written examination with all aids, except any form of communication with other people. The paper must be handed in completely in electronic format, uploaded to a specified indicated address. External examiner. Grades according to the 7-point grading scale.

Exam after conclusion of the course and reexamination after the 4th quarter.

Expected working hours
The teaching method is based on three phase model.

Forelæsninger (24 timer), eksaminatorier (12 timer) og obligatorisk laboratorieøvelser (12 timer).
Educational activities

Language
This course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.