BMB506: Protein chemistry (5 ECTS)

STADS: 01007601

Level
Bachelor course

Teaching period
The course is offered in the autumn semester.
1st quarter.

Teacher responsible
Email: ihk@bmb.sdu.dk

Additional teachers
jonasb@bmb.sdu.dk
bab@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Comment:
Hold S1 er forbeholdt kemistuderende.

Prerequisites:
None

Academic preconditions:
Kemi 1 – Fundamental Chemistry (KE501) and Biology – from molecules to ecosystems has to be passes (BB501). Biomolecular chemistry (BMB501) should be known.

 

Course introduction
To give an introduction to the structure and function of proteins and how they work in a cellular and physiological context through interactions with proteins and other biomolecules.

Qualifications
• Understand the relationship between protein structure and function
• Understand the basic structural elements of a protein and how they have evolved through evolution, how they fold or misfold, and how their structure in determined experimentally.
• Understand how proteins localize within a cell and how they interact with proteins and other biomolecules such as DNA and RNA and how they form protein complexes.
• Understand how protein works in a larger cellular and physiological context exemplified by the immune system.
• Have knowledge about methods to study proteins experimentally and computationally.
• Know how to use tools to visualization the tertiary structure of proteins.
• Understand how knowledge about the protein-function can be used in the development of drugs directed against proteins.

Expected learning outcome


Subject overview
Protein structure
• Tertiary and Quantinary structure
• Determination of protein structure by NMR and X-ray crystallography
• Protein motifs, folds, domains and subunits
• Examples of protein structure

Protein foldning
• Protein foldning pathways
• Chaperones
• Protein dynamics
• Protein struktural evolution
• Prediction of protein structures
• Conformationelle diseases

Struktur og funktion
• Examples of struktur-funktion relationships
• Protein complexes
• Protein topology og methods for in vivo localization of proteins

Molecular physiology
• The immun system
• Mobility
• Blood koagulation

Post translational modificatons of proteins
• Phosphorylation
• Glycosylation

Protein degradation
• Proteases involved in protein turnover
• Lysosomes
• Ubiquitin-proteasom system

Metods in protein chemistry
• Introduction to proteomics
• Introduction to bioinformatic
• Introduction to protein engineering

Literature

• Jeremy M. Berg, John L. Tymoczko and Lubert Stryer: Biochemistry, 7th Edition .

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:

a) The assignments are evaluated with pass/fail internal marking by the teacher and instructor.
The Assignments must be passed to qualify for the exam.
b) Three hours written exam with help material without internet access at the end of the course. External censor and marks following the Danish 7-scale.

Reexamination after 2nd quarter.

Final exam is on English

Expected working hours
The teaching method is based on three phase model.

Forelæsninger (24 timer), eksaminatorier (10 timer) og obligatoriske øvelser indenfor proteiners tertiære struktur ved brug af computer (5 x 2 timer).

(De angivne timetal er vejledende og der vil derfor kunne forekomme afvigelser).

Educational activities

Language
This course is taught in Danish or English, depending on the lecturer.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.