BMB508: Advanced Molecular Biology (10 ECTS)

STADS: 1000801

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
3rd and 4th quarter.

Teacher responsible
Email: kak@bmb.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Comment:
07.05.2007: Hold S2 nedlagt!
04.04.2007:E-time S3 d.10.04.2007 aflyst.

Prerequisites:
None

Academic preconditions:
Passed BB501 Biology from molecule to ecosystem. Knowledge of the content of BMB504 Fundamental Molecular Biology.

Students who has passed BM114 cannot participate in this course.

Course introduction
The course represents a continuation of the course ”Fundamental Molekylær Biologi, and the aim is to provide a coherent understanding of the transmission and exchange of genetic information, to provide knowledge of the characteristics of biological processes at the molecular level in prokaryotes and eukaryotes, and how these processes differ between prokaryotes and eukaryotes. Examples comprising a diverse range organisms including man will be used to illustrate cellular functions and developmental processes.

Qualifications
The students will acquire such knowledge of the principles of molecular biology that they independently will be able to use this knowledge in relevant contexts. Thus, the students will:

• understand and explain similarities and differences in genome organization and molecular functions of prokaryotes and eukaryotes
• understand and explain the relationship between the eukaryotic genome and cellular processes
• understand and explain the fundamental mechanisms the control cellular growth and development
• explain molecular phenomena in a concise manner using an advanced adequate molecular terminology
• possess the necessary scientific qualifications needed to teach at the college level
• possess the necessary foundation to continue advanced studies of molecular biology
• understand and use basic laboratory techniques used in molecular biology
• understand and evaluate information on molecular biology phenomena in media and in the scientific literature

Expected learning outcome


Subject overview
The course will cover the following topics:

1. Eukaryotic genome organization and replication
2. Methods for analysis of gene function, recombinant DNA technology, gene arrays, transgenic and knockout animals, ethical considerations
3. Regulation of transcription in eukaryotes
4. Posttranscriptional regulation, RNA modification, processing, splicing, catalytic RNA and nuclear-cytoplasmic transport
5. Translation of mRNA in eukaryote organisms. Protein localization and export
6. Control of gene activity via cellular signaling (signal transduction) and integration of celluæar signaling in the control of gene expression
7. Metabolic control at the molecular level
8. Control of the cell cycle in eukaryote organisms
9. Cancer at the molecular level, oncogenes, tumor suppressors, DNA damage and repair, signal transduction, hormones and receptors

Literature

• Lodish et al.: Molecular Cell Biology, 5th edition (2003).

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Number of evaluations: 2.

Approval by teacher of report on laboratory exercises. Written examination (4 hours) with no books, and marks according to the Danish 13 grading system with external examinators.

Expected working hours
The teaching method is based on three phase model.

Undervisningen vil bestå af forelæsninger (40 timer), som suppleres med eksaminatorier (24 timer) og laboratorieøvelser (15 timer). Kommunikation mellem lærerne og de studerende med hensyn til forelæsningsnoter, opgaver m.m. vil foregå via SDU’s e-learning system.
Educational activities

Language
No recorded information about the language used in the course.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.