BB523: (5 ECTS)

STADS: 04003101

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
4th quater

Teacher responsible
Email: klp@blology.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Prerequisites:
None

Academic preconditions:
BB508 Animal and plantbiology and BMB501 Biomolecular Chemistry must be passed BMB503 Fundamental biochemistry must be followed.

Course introduction
To introduce basic toxicological terms and analytical tevhniques

Expected learning outcome
After participation in the course the student is expected to be able to:

- Assess toxicological data for pharmaceuticals including extrapolation from animal to human data
- Predict metabolites of compounds based on their chemical structure
- Describe the toxic mechanisms of model compounds on the physioloical and molecular level - Evaluate chromatographic data from the litterature

Subject overview
- Dose-response relationships
-Uptake, distribution, metabolism and excretion of xenobiotica
- the P450 system
- Toxic mechanisms (biochemical/molecular level)
- Extrapolation of toxicolgical data from animal experiments to humans

In the laboratory part the analytical techniques relevant for toxicology is introduced:
- Chromatographic techniques (LC, HPLC, gel eletrophoresis)
- Immunochemical techniques (ELISA)

Literature

• Eds. Mulder, GJ and Dencker. L: Pharmaceutical toxicology, Pharmaceutica! Press 2006.

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
Written exam; External censure; grades according to the 7-scale

Expected working hours
The teaching method is based on three phase model.

Forelæsninger (20 t), eksaminatorietimer (10 t) samt laboratorieøvelser (16 t)
Educational activities

Language
This course is taught in Danish.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.