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BB523: Pharmaceutical Toxicology A (5 ECTS)

STADS: 04009601

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
4th quater

Teacher responsible
Email: wiegand@biology.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 12-14 U144 14-16
Common I Monday 14-16 U49B 18-19
Common I Wednesday 08-10 U49B 14-15, 17
Common I Thursday 14-16 U144 17-18
S1 TE Monday 16-18 U49B 18, 21
S1 TL Tuesday 14-18 U145 15, 17-19
S1 TE Wednesday 10-12 U49B 14-15, 17
S1 TE Thursday 14-16 U144 19
S2 TL Wednesday 14-18 U67 15, 17-19
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Prerequisites:
None

Academic preconditions:
BB508 Animal and plantbiology or BB501 Biology from molecule to ecosystem must be passed. BMB501 Biomolecular Chemistry must be passed. BMB503 Fundamental biochemistry must be followed.

Course introduction
To introduce basic toxicological terms and analytical tevhniques

Expected learning outcome
After participation in the course the student is expected to be able to:
  • Assess toxicological data for pharmaceuticals including extrapolation from animal to human data
  • Predict metabolites of compounds based on their chemical structure
  • Describe the toxic mechanisms of model compounds on the physioloical and molecular level
  • Evaluate chromatographic data from the litterature, conduct chromatographic analysis
Subject overview
  • Dose-response relationships
  • Uptake, distribution, metabolism and excretion of xenobiotica
  • the P450 system – Phase 2 detoxification

  • oxidative stress
  • Toxic mechanisms (biochemical/molecular level)
  • cytotoxicity, genotoxicity, cancerogenity, teratogenity, liver toxicity and kidney toxicity
  • Extrapolation of toxicolgical data from animal experiments to humans


 In the laboratory analytical techniques relevant for toxicology is introduced: 

  • Chromatographic techniques (LC, HPLC, gel eletrophoresis)

    Literature
    • Eds. Mulder, GJ and Dencker. L : Pharmaceutical toxicology, Pharmaceutica! Press 2006.


    Syllabus
    See syllabus.

    Website
    This course uses e-learn (blackboard).

    Prerequisites for participating in the exam
    None

    Assessment and marking:
    a) Active participation in laboratorials are mandatory, presence at min. 80% of the meetings.
    b) Written exam; External censure; grades according to the 7-scale.



    Expected working hours
    The teaching method is based on three phase model.

    Forelæsninger (20 t), eksaminatorietimer (10 t) samt laboratorieøvelser (16 t)
    Educational activities

    Language
    This course is taught in English.

    Remarks
    The exam is in English.

    Course enrollment
    See deadline of enrolment.

    Tuition fees for single courses
    See fees for single courses.