BB523: Pharmaceutical Toxicology A (5 ECTS)

STADS: 04009601

Level
Bachelor course

Teaching period
The course is offered in the spring semester.
4th quater

Teacher responsible
Email: wiegand@biology.sdu.dk

Timetable
Show entire timetable
Show personal time table for this course.

Revison of timetable:
: Labhold S4 oprettet

Prerequisites:
None

Academic preconditions:
BB508 Animal and plantbiology or BB501 Biology from molecule to ecosystem must be passed. BMB501 Biomolecular Chemistry must be passed. BMB503 Fundamental biochemistry must be followed.

Course introduction
To introduce basic toxicological terms and analytical tevhniques

Expected learning outcome
After participation in the course the student is expected to be able to:

• Assess toxicological data for pharmaceuticals including extrapolation from animal to human data
• Predict metabolites of compounds based on their chemical structure
• Describe the toxic mechanisms of model compounds on the physioloical and molecular level
• Evaluate chromatographic data from the litterature, conduct chromatographic analysis

Subject overview

• Dose-response relationships
• Uptake, distribution, metabolism and excretion of xenobiotica
• the P450 system – Phase 2 detoxification

• oxidative stress
• Toxic mechanisms (biochemical/molecular level)
• cytotoxicity, genotoxicity, cancerogenity, teratogenity, liver toxicity and kidney toxicity
• lung toxicity



 In the laboratory analytical techniques relevant for toxicology is introduced: 


• Chromatographic techniques (LC, HPLC, gel eletrophoresis)

Literature

• Eds. Mulder, GJ and Dencker. L: Pharmaceutical toxicology, Pharmaceutica! Press 2006.

Syllabus
See syllabus.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
None

Assessment and marking:
a) Active participation in laboratorials are mandatory, presence at min. 80% of the meetings.
b) Written, digital exam; External censure; grades according to the 7-scale

 

Expected working hours
The teaching method is based on three phase model.

Forelæsninger (20 t), eksaminatorietimer (10 t) samt laboratorieøvelser (16 t)
Educational activities

Language
This course is taught in English.

Remarks
The exam is in English.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.