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BB523: Pharmaceutical Toxicology A (5 ECTS)

STADS: 04009601

Level
Bachelor course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: wiegand@biology.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Monday 12-14 U82 11
Common I Monday 12-14 U140 12
Common I Monday 12-14 U55 13
Common I Wednesday 12-14 U1 10-11,13
Common I Wednesday 12-14 U20 12
Common I Wednesday 10-12 U20 15
Common I Thursday 14-16 U20 14
Common I Friday 08-10 U55 14
S1 TE Tuesday 08-10 U49b 14-15
S1 TL Tuesday 08-12 Yellow Lab. 17-19,21
S1 TE Thursday 14-16 U146 11-13
S2 TE Tuesday 10-12 U145 11-15
S2 TL Thursday 14-18 Yellow Lab. 17,19,21
S2 TL Friday 14-18 Yellow Lab. 21
S3 TE Monday 10-12 U141 15
S3 TL Monday 10-14 Yellow Lab. 18-19,21
S3 TL Wednesday 08-12 Yellow Lab. 17
S3 TE Thursday 12-14 U141 11-14
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Prerequisites:
None

Academic preconditions:
Students enroled in 2012:
FF500 and FF503 must be passed. BMB504, BMB530, SU514 and KE527 must be followed.

Students enroled before 2012:
BB508 and BMB501 must be passed.
BMB530, SU514, BMB504 and KE501 must be followed.

Course introduction
To introduce basic toxicological terms and analytical tevhniques

Expected learning outcome
After participation in the course the student is expected to be able to:

  • Assess toxicological data for pharmaceuticals including extrapolation from animal to human data
  • Predict metabolites of compounds based on their chemical structure
  • Describe the toxic mechanisms of model compounds on the physioloical and molecular level
  • Evaluate chromatographic data from the litterature, conduct chromatographic analysis
Subject overview
  • Dose-response relationships
  • Uptake, distribution, metabolism and excretion of xenobiotica
  • the P450 system – Phase 2 detoxification

  • oxidative stress
  • Toxic mechanisms (biochemical/molecular level)
  • cytotoxicity, genotoxicity, cancerogenity, teratogenity, liver toxicity and kidney toxicity
  • lung toxicity



 In the laboratory analytical techniques relevant for toxicology is introduced: 


  • Chromatographic techniques (LC, HPLC) (gel eletrophoresis)
Literature
  • Edited by Gerard J Mulder and Lennart Dencker: Pharmaceutical Toxicology, Pharmaceutical Press..


Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
Active participation in laboratorials are mandatory, presence at min. 80% of the meetings.

Assessment and marking:
Written, digital exam; External censure; grades according to the 7-scale.

Reexamination in the same exam period or immediately thereafter.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 20 hours
Skills training phase: 26 hours, hereof:
 - Tutorials: 10 hours
 - Laboratory exercises: 16 hours

Educational activities Study phase: 50 hours

Language
This course is taught in English.

Remarks
The exam is in English.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.