2017 Spring 2016 Spring 2015 Spring 2014 Spring 2013 Spring 2012 Spring 2011 Spring 2010 Spring 2009 Spring 2008 Spring
Show the courses of study containg this course Se overgangsordninger
Dansk English

BB523: Pharmaceutical Toxicology A (5 ECTS)

STADS: 04014001

Level
Bachelor course

Teaching period
The course is offered in the spring semester.

Teacher responsible
Email: wiegand@biology.sdu.dk

Timetable
Group Type Day Time Classroom Weeks Comment
Common I Tuesday 10-12 U20 15
Common I Wednesday 08-10 U20 10-13,15
Common I Friday 16-18 U20 10
Common I Friday 08-10 U20 11-13
H1 TE Tuesday 08-10 U142 11-13,15-16
H1 TL Wednesday 14-18 Yellow lab 16-18
H1 TL Friday 14-18 Yellow lab 20
H2 TL Monday 08-12 Yellow lab 17-18,20
H2 TE Tuesday 10-12 U142 16
H2 TE Friday 12-14 U10 11-13,15
H2 TL Friday 08-12 Yellow lab 16
H3 TE Tuesday 14-16 U142 11-13,15-16
H3 TL Wednesday 08-12 Yellow lab 16-18
H3 TL Friday 08-12 Yellow lab 20
Show entire timetable
 Show personal time table for this course.

Prerequisites:
None

Academic preconditions:
Students enroled in 2012:
FF500, FF503, BMB504, BMB530, SU514 and KE527 assumed to be known.

Students enroled before 2012:
BB508, BMB501, BMB530, SU514, BMB504 and KE501 assumed to be known.

Course introduction
To introduce basic toxicological terms and analytical tevhniques

Expected learning outcome
After participation in the course the student is expected to be able to:

  • Assess toxicological data for pharmaceuticals including extrapolation from animal to human data
  • Predict metabolites of compounds based on their chemical structure
  • Describe the toxic mechanisms of model compounds on the physioloical and molecular level
  • Evaluate chromatographic data from the litterature, conduct chromatographic analysis
Subject overview
  • Dose-response relationships
  • Uptake, distribution, metabolism and excretion of xenobiotica
  • the P450 system – Phase 2 detoxification

  • oxidative stress
  • Toxic mechanisms (biochemical/molecular level)
  • cytotoxicity, genotoxicity, cancerogenity, teratogenity, liver toxicity and kidney toxicity
  • lung toxicity



 In the laboratory analytical techniques relevant for toxicology is introduced: 


  • Chromatographic techniques (LC, HPLC) (gel eletrophoresis)
Literature
There isn't any litterature for the course at the moment.

Website
This course uses e-learn (blackboard).

Prerequisites for participating in the exam
Active participation in laboratorials are mandatory, presence at min. 80% of the meetings. (04014012)

Assessment and marking:
4 hours written, digital exam; External censorship; grades according to the Danish 7-mark scale. (04014002)

Reexamination in the same exam period or immediately thereafter.

Expected working hours
The teaching method is based on three phase model.
Intro phase: 20 hours
Skills training phase: 26 hours, hereof:
 - Tutorials: 10 hours
 - Laboratory exercises: 16 hours

Educational activities Study phase: 50 hours

Language
This course is taught in English.

Remarks
The exam is in English.

Course enrollment
See deadline of enrolment.

Tuition fees for single courses
See fees for single courses.